中国全科医学2016，Vol.19Issue(16)：1895-1899,5.DOI:10.3969/j.issn.1007-9572.2016.16.010
免疫指标对妊娠合并系统性红斑狼疮患者妊娠结局的指导意义研究
Significance of Immune Indexes in Predicting Pregnancy Outcomes of Pregnant Patients With Systemic Lupus ;Erythematosus
王慧英 1叶艺璇 2于莎莎 1赵绵松 3张蕊1
作者信息
- 1. 100038 北京市，首都医科大学附属北京世纪坛医院妇产科
- 2. 北京大学医学部
- 3. 100038 北京市，首都医科大学附属北京世纪坛医院免疫风湿科
- 折叠
摘要
Abstract
Objective To investigate the significance of immune indexes in predicting pregnancy outcomes of pregnant patients with systemic lupus erythematosus(SLE). Methods From January 2003 to December 2015,we enrolled 20 pregnant SLE patients who received treatment in Beijing Shijitan Hospital Affiliated to Capital Medical University. The patients all received regular examination and treatment during pregnancy. Antinuclear antibodies, serum complement level and erythrocyte sedimentation rate were selected as immune indexes. Pregnancy outcomes and the incidence of pregnancy complications were compared among patients with different positive conditions of immune indexes. Results Among the 20 patients,there were 13 patients with positive antinuclear antibodies, 5 patients whose serum complement level decreased, and 5 patients whose erythrocyte sedimentation rate increased. Compared with patients who had negative antinuclear antibodies,patients with positive antinuclear antibodies had more cases of early delivery,less average gestational weeks,and lighter body weight of newborns( P﹤0. 05);the number of cases of stillbirth was not significantly different(P﹥0. 05). Compared with patients with normal serum complement level,patients whose serum complement level decreased had more cases of early delivery,less average gestational weeks,and lighter body weight of newborns(P﹤0. 05);the number of cases of stillbirth was not significantly different(P﹥0. 05) . Compared with patients with normal erythrocyte sedimentation rate, patients whose erythrocyte sedimentation rate increased had more cases of premature delivery and stillbirth,less gestational weeks and lighter average body weight of newborns ( P﹤0. 05 ) . Patients with different titers of antinuclear antibodies, serum complement levels, and erythrocyte sedimentation rate were not significantly different in the incidence of complications(P﹥0. 05). Conclusion Pregnant patients with SLE have higher incidence of unfavorable pregnancy outcomes,and differences exist among patients with different conditions of immune indexes. Positive antinuclear antibodies,decrease in serum complement level,and acceleration of erythrocyte sedimentation rate may predict unfavorable pregnancy outcomes.关键词
妊娠/红斑狼疮,系统性/免疫指标/妊娠结局Key words
Pregnancy/Lupus erythematosus,systemic/Immune parameters/Pregnancy outcomes分类
医药卫生引用本文复制引用
王慧英,叶艺璇,于莎莎,赵绵松,张蕊..免疫指标对妊娠合并系统性红斑狼疮患者妊娠结局的指导意义研究[J].中国全科医学,2016,19(16):1895-1899,5.
