摘要
Abstract
Objective To investigate the risk factors for A - β + type KPD. Methods We enrolled 44 patients with A - β + type KPD who were admitted into Zhejiang Hospital from January 2014 to June 2015 as case group,and enrolled 64 patients who were diagnosed as newly onset T2DM but without spontaneous ketosis tendency in the same hospital and period as control group. Data of the subjects were collected,including gender,age,BMI,T2DM family history and hypertension. Random blood glucose,arterial blood gas analysis,blood ketones,urine ketones,GAD - Ab and IA-2Ab were tested. FPG, HbA1c ,F-CP,2 h-CP,TG,TC,LDL-C and UA were tested at admission in control group and the day after ketones turning negative in case group. Results Case group was higher than control group in the levels of FPG,HbA1c and TC,and was lower than control group in the levels of F-CP and 2 h-CP and HOMA2-% B(P < 0. 05). The univariate Logistic regression analysis showed that HbA1c ,TC and HOMA2-% B were risk factors for A - β + type KPD(P < 0. 05). After adjustment of gender,age and BMI,the multivariable Logistic regression analysis showed that low BMI〔OR = 0. 34,95% CI(0. 15,0. 80)〕,high TC〔OR = 1. 39,95% CI(1. 21,1. 66)〕and low HOMA2-% B〔 OR = 0. 17,95% CI(0. 08,0. 39)〕were independent risk factors for A - β + type KPD(P < 0. 05). Conclusion A - β + type KPD is caused by the combined effect of multifactors including BMI,TC and HOMA2-% B. Comprehensive intervention from many aspects is needed in order to prevent its occurrence.关键词
糖尿病/酮病/人体质量指数/胆固醇/危险因素Key words
Diabetes mellitus/Ketosis/Body mass index/Cholesterol/Risk factors分类
医药卫生
