摘要
Abstract
Objective To analyze the effects of diabetes mellitus on the prognosis of patients with primary Barcelona clinic liver cancer(BCLC)stage B hepatocellular carcinoma(HCC)after transcatheter arterial chemoembolization(TACE). Methods From January 2012 to June 2015,we enrolled 151 HCC patients who underwent TACE in the Second Affiliated Hospital of Zhengzhou University and accorded with inclusion and exclusion criteria. Among them,17 HCC patients combined with DM were enrolled as case group,and 134 HCC patients without DM were enrolled as control group. General data and prognosis of the two groups were analyzed,and Cox proportional hazards regression model was used to analyze the influencing factors for the prognosis of BCLC stage B HCC patients after TACE. Results The two groups were not significantly different in gender,age,ALT,Child-Pugh grading,AFP,the sum of tumor diameter,the incidence of portal hypertension,antiviral therapy and times of treatment(P > 0. 05);case group was higher than control group in FPG level(P < 0. 05). With gender, age,having DM or not,ALT,Child-Pugh grading,AFP,the sum of tumor diameter,having portal hypertension or not, receiving antiviral therapy or not and times of treatment as independent variables and prognosis after TACE as dependent variables,univariate Cox proportional hazards regression model analysis showed that the prognosis after TACE of HCC patients had relation with the having DM or not, ALT, Child-Pugh grading, AFP, the sum of tumor diameter, having portal hypertension or not,receiving antiviral therapy or not and times of treatment(P < 0. 05). Multivariate Cox proportional hazards regression model analysis showed that having DM or not,Child-Pugh grading,the sum of tumor diameter,receiving antiviral therapy or not and times of treatment were influencing factors for the prognosis after TACE of HCC patients(P < 0. 05). The 1 -year survival rate,2 - year survival rate and median survival time of control group were 67% ,20% and 17 months. The 1 - year survival rate,2 - year survival rate and median survival time of case group were 44% ,7% and 11 months. By Log - rank and Breslow tests,the two groups were significantly different in survival rate(χ2 = 11. 126,P = 0. 001;χ2 = 10. 430,P = 0. 001). Conclusion DM is an independent risk factor for the prognosis of BCLC stage B HCC patients after TACE.关键词
糖尿病/肝肿瘤/肝动脉化疗栓塞/预后Key words
Diabetes mellitus/Liver neoplasms/Transcatheter arterial chemoembolization/Prognosis分类
医药卫生
