摘要
Abstract
Objective To investigate the risk factors for pulmonary arterial hypertension( PAH)in patients with systemic lupus erythematosus( SLE). Methods By computer - based retrieval and literature retrospect,we searched for literature about the risk factors for PAH in SLE patients from PubMed,CNKI and Wanfang Data with a time range from database establishment to January 2015. Two researchers independently conducted literature screening and extracted data including the first author,publishing time,time for case collection,volume of samples and research factors. Quality evaluation on the included literature was conducted by NOS. According to OR value and its 95% CI,the correlation between each clinical manifestation and laboratory index and PAH in SLE patients was evaluated. Results There were 15 case - control studies included;their NOS scores were all ≥7,and their overall quality were good. SLE patients combined with Raynaud's phenomenon were higher than patients without Raynaud's phenomenon in the risk for PAH〔OR = 3. 96,95% CI(2. 94,5. 34),P < 0. 05〕. There was no significant difference between SLE patients with or without cutaneous vasculitis in the risk for PAH(P > 0. 05). SLE patients with positive anti - RNP antibody were higher than patients with negative anti - RNP antibody in the risk for PAH〔OR = 3. 32, 95% CI(2. 37,4. 66),P < 0. 05〕. SLE patients with positive anti ACL-IgG antibody were higher than patients with negative anti ACL-IgG antibody in the risk for PAH〔 OR = 3. 36,95% CI(2. 37,4. 76),P < 0. 05〕. SLE patients combined with serositis were higher than SLE patients without serositis in the risk for PAH〔OR = 2. 63,95% CI(1. 50,4. 59),P < 0. 05〕. SLE patients combined with interstitial lung disease were higher than patients without interstitial lung disease in the risk for PAH〔OR = 4. 65,95% CI(3. 13,6. 88),P < 0. 05〕. Conclusion Raynaud's phenomenon,positive anti - RNP antibody, positive anti ACL-IgG antibody,serositis and interstitial lung disease are risk factors for PAH in SLE patients.关键词
红斑狼疮,系统性/肺动脉高压/危险因素/Meta 分析Key words
Lupus erythematosus,systemic/Pulmonary hypertension/Risk factors/Meta - analysis分类
医药卫生
