中国中医药信息杂志2016，Vol.23Issue(7)：17-21,5.DOI:10.3969/j.issn.1005-5304.2016.07.005
手足口病中医证型与血清炎性细胞因子、 T细胞亚群、NK细胞相关性分析
Analysis on Correlation Between TCM Syndromes of Hand, Foot and Mouth Disease and Serum Proinflammatory Cytokines, T Cell Subgroup and NK Cells
摘要
Abstract
Objective To study the correlation between hand, foot and mouth disease (HFMD) in lung-spleen damp-heat syndrome, syndrome of stagnation and steaming due to damp-heat, and syndrome of stirring wind due to toxic-heat with IL-6, PCT, CRP, CD3+, CD4+, CD8+ and NK cells.Methods Ninety patients with HFMD were randomly selected, dividing into lung-spleen damp-heat syndrome, syndrome of stagnation and steaming due to damp-heat, and syndrome of stirring wind due to toxic-heat, 30 cases for each syndrome. IL-6, PCT, CRP, CD3+, CD4+, CD8+ and NK cells were detected, and the distribution of above indicators in the three syndromes were analyzed.Results Levels of IL-6, PCT and CRP in syndrome of stirring wind due to toxic-heat were significantly higher than those in lung-spleen damp-heat syndrome and syndrome of stagnation and steaming due to damp-heat, with statistical significance (P<0.01); There was statistical significance in absolute value counting of CD3+, CD4+, CD8+ and NK cells among the three syndromes (P<0.01); There was statistical significance in the percentage of CD3+ cells in syndrome of stirring wind due to toxic-heat and lung-spleen damp-heat syndrome (P<0.01) and syndrome of stagnation and steaming due to damp-heat (P<0.05); There was statistical significance in the percentage of CD4+ cells syndrome of stirring wind due to toxic-heat and lung-spleen damp-heat syndrome (P<0.05) and syndrome of stagnation and steaming due to damp-heat (P<0.01); There was statistical significance in the percentages of CD8+ and NK cells in the three syndromes (P<0.01).Conclusion Proinflammatory cytokines, proinflammatory markers, and T cell sub-group related to HFMD in lung-spleen damp-heat syndrome, syndrome of stagnation and steaming due to damp-heat, syndrome of stirring wind due to toxic-heat are not only correlative with morbidity, but also with the severity of diseases and prognosis, which can relatively effectively evaluate the state of diseases and judge prognosis.关键词
手足口病/白细胞介素-6/降钙素原/C反应蛋白/T细胞亚群Key words
hand, foot and mouth disease/IL-6/calcitonin original/C-reactive protein/T cell sub-group分类
医药卫生引用本文复制引用
黄伟,李芹..手足口病中医证型与血清炎性细胞因子、 T细胞亚群、NK细胞相关性分析[J].中国中医药信息杂志,2016,23(7):17-21,5.基金项目
国家科技重大专项-艾滋病和病毒性肝炎等重大传染病防治（2012ZX10004301-005）；福州市卫生系统科技计划项目 （）
