中国中医药信息杂志2016，Vol.23Issue(7)：30-34,5.DOI:10.3969/j.issn.1005-5304.2016.07.008
白头翁汤对溃疡性结肠炎黏膜愈合的影响及部分机制研究
Effects ofBaitouweng Decoction on Intestinal Mucosal Healing of Ulcerative Colitis and Study on Partial Mechanism
摘要
Abstract
Objective To detect the levels of tumor necrosis factor-α (TNF-α) and interleukin 10 (IL-10) in the plasma of patients with ulcerative colitis (UC); To investigate the clinical efficacy ofBaitouweng Decoction for UC and its influence on intestinal mucosal healing and partial mechanism.Methods Totally 66 patients with UC were randomly assigned to the treatment group and the control group. Patients in the treatment group were treated with Baitouweng Decoction (oral and enema treatment) and those in the control group took Mesalazine for 4 weeks. Before and after treatment, the therapeutic effects were assessed by Mayo scoring system and the grading of activities was evaluated by Baron Endoscope. Serum levels of TNF-α and IL-10 were detected by ELISA. Besides, another 20 healthy volunteers were recruited as the healthy control group for comparison.Results The endoscopic remission rate was 51.4% (19/35) in treatment group, higher than that of the control group (25.8%, 8/31,P<0.05). The clinical remission rate and efficacy rate in the treatment group were 74.2% and 88.6% respectively, higher than those of the control group (45.1% and 64.5%,P<0.05). The histological remission rate and efficacy rate in the treatment group were 25.7% and 54.3% respectively, higher than those of the control group (16.1% and 35.5%), without statistical significance (P>0.05). Serum levels of TNF-α were obviously positive correlated with Mayo score, Baron score and histology score (r=0.836, 0.735, 0.527,P<0.01). Serum levels of IL-10 were obviously negative correlated with Mayo score, Baron score and histology score (r=-0.704, -0.695, -0.509,P<0.01). Compared with pre-treatment, the serum levels of TNF-α significantly decreased (P<0.01), while the serum levels of IL-10 significantly increased (P<0.01) after treatment withBaitouweng Decoction.ConclusionBaitouweng Decoction (oral and enema treatment) is effective and safe in patients with UC. Its effects might be involved in regulating the imbalance of pro-inflammatory factors and anti-inflammatory factors, and promoting mucosal healing.关键词
溃疡性结肠炎/白头翁汤/肿瘤坏死因子-α/白细胞介素-10Key words
ulcerative colitis/Baitouweng Decoction/tumor necrosis factor-α/interleukin-10分类
医药卫生引用本文复制引用
谭朝晖,刘荣火,邹立华,曹平,胡红松..白头翁汤对溃疡性结肠炎黏膜愈合的影响及部分机制研究[J].中国中医药信息杂志,2016,23(7):30-34,5.基金项目
深圳市科技计划项目 （）
