摘要
Abstract
Objective To investigate the effect of different usage of dexmedetomidine on perioperative stress reactions in patients undergoing gynecological surgery.Methods 87 patients undergoing gynecological surgery in our hospital from October 2013 to October 2014 were selected and randomly divided into blank group (29 cases),control group (29 cases),and observation group (29 cases) according to the random number table method.Patients in blank group were treated with routine anesthesia induction;patients in control group were treated with dexmedetomidine 1.0μg/kg and continuous intravenous infusion of 0.4μg/(kg·min) before anesthesia induced intubation;patients in observation group were treated with intravenous injection of dexmedetomidine 0.5μg/kg in 15 min before anesthesia induced intubation.Preoperative,intraoperative and postoperative norepinephrine (NE),epinephrine (E) concentrations and blood glucose (Glu) level in three groups were statistically analyzed.The incidence of adverse reactions in three groups were observed.Results After operation,the levels of NE,E,and Glu in control group and observation group increased to (275.2±23.3)pg/ml,(153.7±17.6)pg/ml,(9.7±3.2) mmol/L and (193.6± 19.7)pg/ml,(103.5±18.9)pg/ml,(6.3±1.5) mmol/L respectively;there were statistically significant differences in indexes mentioned above between two groups (P＜0.05),with statistically significant differences compared with those before and during operation in the same group,and those in blank group after operation (P＜0.05).The incidence of adverse reactions in blank group,control group,and observation group were 20.7％,13.8％,and 10.3％,without statistically significant difference among three groups (x 2=1.375,P＞0.05).Conclusion Dexmedetomidine can effectively reduce stress reactions in patients undergoing gynecological surgery,and stress reactions in patients are the minimum when the dosage is 0.5μg/kg,with good safety.关键词
右美托咪定/妇科手术/应激反应/剂量Key words
Dexmedetomidine/Gynecological surgery/Stress reactions/Dose
