国际口腔医学杂志2016，Vol.43Issue(4)：445-448,4.DOI:10.7518/gjkq.2016.04.016
双膦酸盐及其相关性颌骨坏死的机制和治疗
Mechanism and treatment of bisphosphonate-related osteonecrosis of the jaw
摘要
Abstract
Bisphosphonate-related osteonecrosis of the jaw(BRONJ) is a severe complication that occurs frequently in patients subjected to long-term bisphosphonate treatment for osteoporosis, multiple myeloma, and other skeletal-related events induced by metastatic malignant diseases, such as breast, prostate, and lung cancers. The development of BRONJ is associated with some risk factors, such as bisphosphonate potency and administration model, dental extraction, and poor-fitting dentures. The definition, staging, and treatment guidelines of patients with BRONJ were established by the American Association of Oral and Maxillofacial Surgeons in 2007 and then updated in 2009 and 2014. Although BRONJ has been extensively investigated, the pathogenesis of this disease has yet to be fully elucidated, and corresponding treatments have remained controversial. This article briefly introduces new insights into the pathogenesis and treatments of BRONJ.关键词
双膦酸盐/双膦酸盐相关性颌骨坏死/发病机制/治疗措施Key words
bisphosphonate/bisphosphonate-related of osteonecrosis of the jaw/pathogenesis/treatment measures分类
医药卫生引用本文复制引用
魏斌,孙国文..双膦酸盐及其相关性颌骨坏死的机制和治疗[J].国际口腔医学杂志,2016,43(4):445-448,4.基金项目
江苏省临床医学科技专项项目（BL2013005）；江苏省卫生厅课题项目（H201441）；南京市科技发展计划（201503038）；南京市医学科技发展计划 （）
