国际口腔医学杂志2016，Vol.43Issue(4)：449-455,7.DOI:10.7518/gjkq.2016.04.017
内外源性应力对间质干细胞成软骨分化的调控
Regulation of external and internal forces on the chondrogenic differentiation of mesenchymal stem cells
摘要
Abstract
With advancements in tissue engineering, therapies for osteoarthritis have been developed. Mesenchymal stem cells(MSC) can differentiate into various cell types and be used as an optimum source of cells for tissue engineering to produce an engineered cartilage. However, the efficient and stable stimulation of chondrogenetic differentiation of MSC is a key challenge in cartilage tissue engineering. Further studies have been conducted to investigate mechanical stimulation and to determine the internal and external forces that can stimulate the chondrogenic differentiation of MSC and maintain their phenotypes. This review summarizes the research progress on the effects of internal and external forces on the chondrogenic differentiation of MSC.关键词
间质干细胞/力学刺激/力学信号转导/干细胞分化/成软骨分化Key words
mesenchymal stem cell/mechanical stimulation/mechanotransduction/stem cell differentiation/chondrogenesis分类
生物科学引用本文复制引用
邱静怡,万凌云,赵志河,李娟..内外源性应力对间质干细胞成软骨分化的调控[J].国际口腔医学杂志,2016,43(4):449-455,7.基金项目
国家自然科学基金（31470904，31370992）；四川省科技支撑计划 （）
