国际口腔医学杂志2016，Vol.43Issue(4)：468-472,5.DOI:10.7518/gjkq.2016.04.020
蜗牛蛋白调控腭部发生发育的机制
Mechanisms of the transcript factor Snail during palatogenesis
摘要
Abstract
Snail is involved in epithelial-to-mesenchymal transformation(EMT), programmed cell death(PCD), and medial epithelial seam(MES) cell migration during palatogenesis. The Snail expression becomes upregulated without inhibiting transforming growth factor(TGF)-β3 and causes cleft palate. Snail gene-encoding transcript factors, namely, Snail1, Snail2, and Snail3, can combine with the promoter of E-cadherin and inhibit its expression; these factors then induce EMT during embryogenesis and tumor metastasis. Snail is also a critical factor of MEE/MES cell survival and cell migration. MicroRNA(miRNA) are another important factor in embryogenesis. Variation in the expression pattern and mRNA binding sites of miRNA can lead to craniofacial anomalies. This review introduces the structure, functions, and expression of Snail during palatogenesis. This review also discusses the relation of Snail to EMT, PCD, and cell survival during the disappearance of MEE/MES. This review also describes the mechanisms by which miRNA regulate Snail to control the disappearance of MEE/MES.关键词
蜗牛蛋白/腭部发育/先天性腭裂/微小RNAKey words
Snail/palatogenesis/cleft palate/microRNA分类
生物科学引用本文复制引用
李泓钰,黄洪章..蜗牛蛋白调控腭部发生发育的机制[J].国际口腔医学杂志,2016,43(4):468-472,5.基金项目
国家自然科学基金 （）
