国际口腔医学杂志2016，Vol.43Issue(4)：477-481,5.DOI:10.7518/gjkq.2016.04.022
转化生长因子-β超家族成员在牙本质发生发育中的作用
Roles of transforming growth factor-β superfamily in dentinogenesis
摘要
Abstract
Transforming growth factor(TGF)-β superfamily is a group of essential growth factors involved in the regulation of cell proliferation, differentiation, and apoptosis. TGF-β, bone morphogenetic protein(BMP), growth differentiation factor(GDF), activin(ACT), inhibin and so on, share a set of similar spatial structures of proteins. Dentin, as the important supportive part of tooth structure, is formed with mineralized matrix, which secreted by odontoblasts. During dentin formation, TGF-β1 participates in the regulation of matrix formation, mineralization, and the odontoblasts arrangement; BMP involved in the adjustment of many transcription factors’ expression and mediated epithelial-mesenchymal interaction in dentification; while GDF play roles in periodontal development and ACT regulates cell metabolism, inmmune response, damage repairment and so on. This article reviewed the advances on the roles of TGF-βsuperfamily in dentinogenesis.关键词
转化生长因子/牙本质/牙发生发育Key words
transforming growth factor/dentin/dentification and development分类
生物科学引用本文复制引用
陈尽欢,孙建勋,陈新梅..转化生长因子-β超家族成员在牙本质发生发育中的作用[J].国际口腔医学杂志,2016,43(4):477-481,5.基金项目
国家自然科学基金 （）
