南阳师范学院学报2016，Vol.15Issue(6)：17-21,5.
大蓟中木脂素类化学成分研究
Studies on lignans from Cirsium japonicum
摘要
Abstract
To investigate the chemical constituents of Cirsium japonicum, nine lignans were obtained by column chromatography on silica gel , macroporous resin ( Diaion-101 ) , Sephadex LH-20 , and TLC for separation and purification.Their structures were identified as justicidin B (1), 6′-hydroxy justicidin A (2), 6′-hydroxy justi-cidin B (3), diphyllin (4), justicidin A (5), 6-hydroxy-4-(4-methoxyl-3-methoxyphenyl )-3-hydroxymethyl-5-methoxyl-3,4-dihydro(3R,4S)-2-aldehydenaphthalene (6), 6-hydroxy-4-(4-methoxyl-3-methoxyphenyl)-3-hydroxymethyl-7-methoxyl-3,4-dihydro (3R,4S)-2-aldehydenaphthalene (7), 4′-demethyl podophyllotoxin (8), podophyllotoxin (9) by spectroscopic data and references .Compounds (1 ~9) were isolated from this plant for the first time .Meanwhile , Compounds ( 1~9 ) were evaluated for their hepatoprotective activities a-gainst D-galactosamine-induced toxicity in HL-7702 cells using a MTT colorimetric method .关键词
大蓟/木脂素/肝保护活性Key words
Cirsium japonicum/lignans/hepatoprotective activities分类
医药卫生引用本文复制引用
宁恺佳,马勤阁,张肃,曹康宁..大蓟中木脂素类化学成分研究[J].南阳师范学院学报,2016,15(6):17-21,5.基金项目
河南省高等学校重点科研项目（15A350009）；南阳师范学院校级专项科研项目（ZX201404）；南阳市科技攻关项目 （）
