陕西医学杂志2016，Vol.45Issue(7)：915-918,4.DOI:10.3969/j.issn.1000-7377.2016.07.61
H-FABP在急性心肌梗死早期诊断中的临床应用价值分析
Clinical application value of H-FABP in the early diagnosis of acute myocardial infarction
摘要
Abstract
Objective:To study the serum myocardial fatty acid binding protein (H‐FABP) in early diagnosis of patients with acute myocardial infarction (AMI) clinical application effect ,and to explore the sensitive indexes of early diagnosis of AMI .Methods:Choose 98 cases of patients with suspected acute coronary syndrome (ACS) and 30 cases of healthy people (healthy group) were collected in patients with onset of 1~3h ,4~8h ,9~15h in venous blood ,serum was detected in H‐FABP ,creatine kinase isoenzyme (CK‐MB) ,troponin (CTnI ) ,myoglobin (MYO) and compare within the group ,in the final clinical diagnosis as the gold standard ,calculation of the four kinds of serum cardiac markers for early diagnosis of AMI diag‐nostic evaluation index .Results:The first time 1 ~ 3h ,AMI group of patients with H‐FABP ,MYO index check out of the water ,on average ,significantly higher than healthy group ,the patients with UAP group ,the ACS group the differences were statistically significant ;and CK‐MB ,CTnI the detection of the health group ,UAP group ,the non-ACS patients ,the differ‐ence was not statistically significant ;AMI group H‐FABP ,MYO ,CK‐MB ,CTnI detectable levels in the incidence was signifi‐cantly higher than the 4 ~ 8h period healthy group ,UAP group ,the non-ACS group differences were statistically significant ;in the pathogenesis of 9 ~ 15h period CK‐MB ,CTnI to a higher level and significantly higher than the healthy group ,UAP group ,the non-ACS patients ,the differences were statistically significant .H‐FABP early diagnosis and compare the final clinical diagnosis ,the correct diagnosis of AMI in 41 patients ,46 patients with non-AMI ,consistent rate of clinical diagnosis and the final diagnosis result Kappa = 0 .775;CK‐MB early diagnosis of AMI patient concordance rates Kappa = 0 .357;con‐sistent rate CTnI early diagnosis of AMI in patients with Kappa = 0 .171;consistent rate MYO early diagnosis of AMI in pa‐tients with Kappa = 0 .487 .Conclusion:H‐FABP in early acute myocardial infarction appears significantly elevated levels ,and the final diagnosis and clinical diagnosis of high consistency ..关键词
心肌型脂肪酸结合蛋白/心肌梗塞/诊断Key words
Heart type fatty acid binding protein/Myocardial infarction/diagnosis分类
医药卫生引用本文复制引用
肖林,郭梅,范瑞云..H-FABP在急性心肌梗死早期诊断中的临床应用价值分析[J].陕西医学杂志,2016,45(7):915-918,4.基金项目
天津市科委自然基金资助项目 （）
