特产研究2016，Vol.38Issue(2)：12-16,5.DOI:10.16720/j.cnki.tcyj.2016.02.003
鹿茸蛋白促进小鼠骨折愈合的实验研究
Experimental Study of Velvet Antler Protein in Accelerating Fracture Healing in Mice
摘要
Abstract
The objective of this study was to investigate the effects of velvet antler protein (VAP) on fracture healing in mice .Analyzing X-ray radiography ,tissue pathological slices ,serum IGF-1 and alkaline phosphatase(ALP) content to observe the effects of intramuscular injection VAP on fracture model mice .Compared with the control group and Jiegupian group ,intramuscular injection VAP can obviously accelerated frac-ture healing .Fracture line disappeared and marrow cavity unobstructed from the test of X ray so 58mg/kg VAP can significantly promote the ef-fect of fracture healing in mice ;The HE staining shows 58mg/kg VAP makes bone marrow cavity was saturated with large number of bone mar-row cells and more dense bony connection .Given 58mg/kg VAP results serum IGF-1 and ALP levels higher than the control group and Jiegu-pian group .The dose of 58mg/kg VAP had the effect on promoting bone formation and fracture healing with high level of ALP and IGF -1 in mice blood .关键词
鹿茸蛋白/骨折愈合/X光/组织切片/生化指标Key words
velvet antler protein/fracture healing/X-ray radiography/histology analysis/biochemical analysis分类
医药卫生引用本文复制引用
刘继华,杨苗,吴迪,王春红,段金月,尹建元,王云华,高兵,常彤..鹿茸蛋白促进小鼠骨折愈合的实验研究[J].特产研究,2016,38(2):12-16,5.基金项目
吉林省科技厅重点攻关项目 （）
