西安交通大学学报（医学版）2016，Vol.37Issue(4)：609-612,4.DOI:10.7652/jdyxb201604029
microRNA-451在弥漫性大 B 细胞淋巴瘤患者血浆中的表达及意义
Expression levels and clinical significance of microRNA-451 in the plasma of patients with diffuse large B lymphoma
摘要
Abstract
Objective To explore the expression level and clinical significance of microRNA‐451 (miR‐451) in the plasma of patients with diffuse large B lymphoma (DLBCL) .Methods We enrolled 27 patients with DLBCL and 27 healthy controls for the study .The plasma level of miR‐451 was detected by reverse transcription polymerase chain reaction (RT‐PCR) .Then we analyzed the relationship between the plasma level of miR‐451 and pathological characteristics of DLBCL .Results The plasma level of miR‐451 in the patients with DLBCL was significantly lower than in healthy controls [(0 .41 ± 0 .15) vs .(0 .64 ± 0 .21)] (P<0 .01) .However ,the plasma level of miR‐451 was not significantly correlated with the patients'gender ,age ,serum LDH level or primary site (P>0 .05) ,but with Ann Arbor tumor stage and IPI score ( P< 0 .05 ) .Conclusion The plasma level of miR‐451 decreases in patients with DLBCL ,which indicates that miR‐451 may participate in the pathology of DLBCL .关键词
弥漫性大B细胞淋巴瘤/microRNA-451/定量PCRKey words
diffuse large B lymphoma/microRNA-451/RT-PCR分类
医药卫生引用本文复制引用
张平..microRNA-451在弥漫性大 B 细胞淋巴瘤患者血浆中的表达及意义[J].西安交通大学学报（医学版）,2016,37(4):609-612,4.基金项目
国家自然科学基金资助项目（No ．81471175） Supported by the National Natural Science Foundation of China （）
