右江医学2016，Vol.44Issue(3)：249-253,5.DOI:10.3969/j.issn.1003-1383.2016.03.001
广西壮族人群 IL-27基因位点 rs4740与 rs181206多态性研究
A study of polymorphism of IL-27 gene locus rs4740 and rs181206 of Zhuang population in Guangxi
摘要
Abstract
Objective To analyze distribution frequency of genotype and allele of interleukin-27(IL-27)single nucleo-tide polymorphism(SNP)locus rs4740 and rs181206 of Zhuang population in Guangxi,and to analyze distribution differ-ences among different races.Methods SNaPshot SNP typing technology was used to test IL-27 gene SNP locus rs4740 and rs181206 genotypes in 150 cases of Zhuang population in Guangxi,and comparing the above-mentioned rs4740 and rs181206 genotypes to SNP typing data from four populations(Europe,Africa,Japan,and Beijing)on the international human genome haplotype map(HapMap).And then,differences between IL-27 gene SNP locus rs4740 and rs181206 genotypes and allele fre-quencies among the above-mentioned five groups were analyzed.Results Polymorphism of interleukin gene rs4740 and rs181206 was found in Zhuang population in Guangxi.Difference of genotype and allele frequency of rs4740 locus in Zhuang population in Guangxi and those of African population and Japanese population was statistically significant(P<0.05),but difference of those of European population and Beijing population was not statistically significant(P>0.05).However,differ-ences of genotype and allele frequency of rs181206 locus in Zhuang population in Guangxi and those of European population, African population,Japanese population and Beijing population were all statistically significant(P<0.05).Conclusion There is difference between SNP locus rs4740 and rs181206 genotypes and allele distribution frequencies of Zhuang population in Guangxi and those of population in other areas,this difference may lead to differences in the incidence and clinical manifesta-tions of certain diseases in different regions.关键词
白细胞介素 27/单核苷酸多态性/基因型/种族Key words
IL-27/single nucleotide polymorphism/genotype/race分类
医药卫生引用本文复制引用
陈善萍,郭钊,韦宝斌,徐冲,韦贵将,唐毓金,王俊利..广西壮族人群 IL-27基因位点 rs4740与 rs181206多态性研究[J].右江医学,2016,44(3):249-253,5.基金项目
国家自然科学基金 （）
