医药导报2016，Vol.35Issue(7)：752-757,6.DOI:10.3870/j.issn.1004-0781.2016.07.019
纳米给药系统的抗肿瘤药物联合治疗策略∗
Nanoparticle-based Combination Therapies for Cancer Treatment
摘要
Abstract
Combination chemotherapy and nanoparticle drug delivery are two promising strategies in cancer treatment. The use of multiple therapeutic agents in combination provides synergistic effects among different drugs against cancer cells and suppresses drug resistance through distinct mechanisms of action.Nanocarriers can improve anti-tumor effects of drugs and reduce systemic toxicity through delivering drugs into the tumor tissue specially. Recently, many studies are aiming to encapsulate multiple agents into nanocarriers to optimize the anti-tumor effects. In the present review, the recent advances of nanoparticle platforms applied with co-delivering two or more drugs were summarized and the various combination strategies based on nanoparticles in oncology were discussed.关键词
纳米给药系统/药物联用/肿瘤治疗/多药耐药/协同作用Key words
Nanoparticle drug delivery/Drug combination/Cancer treatment/Multiple-drug resistance/Synergistic action分类
医药卫生引用本文复制引用
叶鹏,张文典,杨坦,盖永康,项光亚..纳米给药系统的抗肿瘤药物联合治疗策略∗[J].医药导报,2016,35(7):752-757,6.基金项目
国家自然科学基金资助项目(81503015) （81503015）
