医药导报2016，Vol.35Issue(7)：789-792,4.DOI:10.3870/j.issn.1004-0781.2016.07.028
乌司他丁改善体外循环术患者围手术期炎性反应的系统评价
Effects of Ulinastatin on Perioperative Inflammatory Response During Cardiopulmonary Bypass:A Systematic Review
沈述威 1夏中元 1陈榕 1赵博 1冷燕 1刘敏1
作者信息
- 1. 武汉大学人民医院麻醉科，武汉 430060
- 折叠
摘要
Abstract
Objective To evaluate the effects of ulinastatin on perioperative inflammatory response during cardiopulmonary bypass. Methods Comprehensive search of PubMed,EMbase,the Cochrane Library,CECDB,CQVIP,CNKI databases was conducted for randomized controlled trials(RCTs) published from January 1994 to June 2014.The included studies were evaluated strictly and the extracted data were analyzed by RevMan 5.2. Results A total of 7 RCTs including 335 patients were included,and 154 patients were in the experimental group,while 181 patients were in the control group.In the experimental group, patients were given Ulinastatin during surgery. System evaluation results show that, the concentration of TNF-α [ SMD (95%CI) were -3.48(-4.64,-2.31)] and IL-6 [SMD(95%CI) were -3.04(-4.54,-1.54)] in experimental group at 1 h after weaning from CPB were significantly lower than those in control group. Conclusion Ulinastatin used perioperatively in cardiopulmonary bypass can significantly reduce postoperative inflammation.关键词
乌司他丁/体外循环术/围手术期Key words
Ulinastatin/Cardiopulmonary bypass surgery/Perioperative分类
医药卫生引用本文复制引用
沈述威,夏中元,陈榕,赵博,冷燕,刘敏..乌司他丁改善体外循环术患者围手术期炎性反应的系统评价[J].医药导报,2016,35(7):789-792,4.
