中国医学创新2016，Vol.13Issue(17)：26-29,4.DOI:10.3969/j.issn.1674-4985.2016.17.007
布渣叶总生物碱在高脂血症大鼠中的作用机制分析
Mechanism Analysis of Paniculata Total Alkaloids in Hyperlipidemia Rats
摘要
Abstract
Objective:To study mechanism analysis of Paniculata Total Alkaloids in hyperlipidemia rats. Method:Paniculata Total Alkaloids were extracted,separated and purified,Wistar rats model were made by high fat feed,all were randomly divided into control group,positive control group,model control group and Paniculata Total Alkaloids low,medium and high dose group according to different lavage way,each for 10 cases,total cholesterol(TC),triglycerides(TG),fatty acid synthase (FAS) and carnitine palmitoyl transferase 1 (CPT) levels were determined.Result:Serum and liver lipids TC,TG levels of positive control group,model control group,Paniculata Total Alkaloids group were significantly lower than control group(P<0.05),the above index of Paniculata Total Alkaloids group were significantly lower than positive control group(P<0.05),with the dose of Paniculata Total Alkaloids increasing,serum and liver lipids TC,TG levels were declined(P<0.05).FAS level of positive control group, model control group,Paniculata Total Alkaloids group were significantly lower than control group,CPT-1 level were obviously higher than control group,FAS levels of Paniculata Total Alkaloids group significantly lower than positive control group,CPT-1 level were obviously higher than positive control group (P<0.05),with the doses of Paniculata Total Alkaloids increasing,FAS level were declined,CPT-1 level were increased(P<0.05).Conclusion:Paniculata Total Alkaloids plays a therapic role for hyperlipemia by lowering FAS and increasing CPT-1 content.关键词
布渣叶/总生物碱/高脂血症Key words
Paniculata/Total Alkaloids/Hyperlipidemia引用本文复制引用
冯亮,罗文汇..布渣叶总生物碱在高脂血症大鼠中的作用机制分析[J].中国医学创新,2016,13(17):26-29,4.基金项目
广东省中医药课题 （）
