中国医学创新2016，Vol.13Issue(17)：30-33,4.DOI:10.3969/j.issn.1674-4985.2016.17.008
脑钠肽与血乳酸清除率在A型主动脉夹层术后呼吸功能不全的临床研究
Clinical Study of Brain Natriuretic Peptide and Blood Lactate Clearance Rate in Type A Aortic Dissection of Postoperative Respiratory Insufficiency
摘要
Abstract
Objective:To observe dynamic changes of brain natriuretic peptide(BNP) levels and blood lactate clearance rate for postoperative respiratory insufficiency of type A aortic dissection surgery,in order to assess the extent of lung injury,guide the role of weaning.Method:A total of 42 patients with postoperative respiratory insufficiency of type A aortic dissection surgery in our hospital were selected from October 2010 to October 2015.According to patients with oxygen index to the acute lung injury group (ALI) (oxygenation index: 200 mm Hg≤PaO2/FiO2≤300 mm Hg) and ARDS group (PaO2/FiO2≤200 mm Hg),according to ventilator weaning results for the weaning success group (successful weaning and extubation and 48 h without complex in ventilation or support) the weaning failure group (48 h after weaning need to be ventilated again).Blood lactic acid,blood gas analysis and brain natriuretic peptide were observed at transferred,6,24,48 h,3 d until turn out.Result:All patients with postoperative respiratory insufficiency of type A aortic dissection surgery had higher blood lactic acid in the patients with respiratory insufficiency after operation,into the obvious,then gradually decreased,BNP levels increased gradually,the ALI group reached the peak at 3 d and 5 d dropped significantly, oxygenation index improved significantly in the ARDS group reached the peak at the 5 d,7 d dropped significantly, oxygenation index improved significantly.The weaning successful group was compared with the weaning failure group,BNP level was significantly lower,blood lactate clearance rate was higher and the differences between the two groups had statistical significance(P<0.05).Conclusion:Respiratory function of patients with the more severe,in patients with brain natriuretic peptide content is higher and the blood lactic acid clearance rate is low, postoperative weaning more difficult,BNP levels and blood lactic acid clearance rate is postoperative respiratory insufficiency of type A aortic dissection surgery weaning reference index.关键词
脑钠肽/血乳酸清除率/A型主动脉夹层/呼吸功能不全/撤机Key words
Brain natriuretic peptide/Blood lactate clearance rate/Type A aortic dissection/Respiratory insufficiency/Ventilator weaning引用本文复制引用
欧阳晓仙,刘易林,李莉,吴金平,廖成全..脑钠肽与血乳酸清除率在A型主动脉夹层术后呼吸功能不全的临床研究[J].中国医学创新,2016,13(17):30-33,4.基金项目
广东省医学科研基金项目 （）
