中国医学创新2016，Vol.13Issue(18)：48-50,51,4.DOI:10.3969/j.issn.1674-4985.2016.18.014
地塞米松联合尿激酶治疗结核性胸膜炎的疗效及对胸腔积液IL-6、IL-8和hs-CRP水平的影响
Effect and Impact of IL-6,IL-8 and hs-CRP in Pleural Effusion in Patients with Tuberculous Pleuritis Treated with Dexamethasone and Urokinase
摘要
Abstract
Objective:To discuss the impact of IL-6,IL-8 and hs-CRP in pleural effusion in patients with Tuberculous pleuritis treated with Dexamethasone and Urokinase.Method:A total of 64 patients with tuberculous pleuritis from January 2013 to January 2015 in our hospital were randomly selected and divided into 32 patients of them accepted with conventional oral anti-TB drugs,pleural puncture pumping fluid and intrapleural injection of urokinase were taken as the control group while the other 32 patients of them accepted with intrapleural injection of Dexamethasone were taken as the observation group.The clinical effect and the improvement of clinical symptoms of two group were compared,and the levels of IL-6,IL-8 and hs-CRP before and after 3,7 d treatment were detected.Result:The total effective rate of the observation group was more than that of the control group,differences between two group had statistical significance(P<0.05).The time of hydrothorax disappeared and the pleural thickness of the observation group were more than those of the control group,differences had statistical significance(P<0.05).The incidence of pleural adhesions of the observation group was 9.38%,it was lower than that of the control group,difference between two group had statistical significance(P<0.05).The levels of IL-6,IL-8 and hs-CRP in pleural effusion after 3,7 d treatment of the observation group were notably lower than those of the control group,differences between two groups were statistically significant(P<0.05).Conclusion:Dexamethasone combined with Urokinase in the treatment of tuberculous pleuritis can improve the clinical symptoms and reduce the levels of IL-6, IL-8 and hs-CRP with exact clinical effect,it is worth of clinical use.关键词
地塞米松/尿激酶/结核性胸膜炎/白细胞介素-6/白细胞介素-8/C-反应蛋白Key words
Dexamethasone/Urokinase/Tuberculous pleuritis/Interleukin-6/Interleukin-8/C-reactive protein引用本文复制引用
钟红剑,刘腊香,陈文胜,杨澍..地塞米松联合尿激酶治疗结核性胸膜炎的疗效及对胸腔积液IL-6、IL-8和hs-CRP水平的影响[J].中国医学创新,2016,13(18):48-50,51,4.基金项目
深圳市科技计划资助项目 （）
