北京中医药大学学报2016，Vol.39Issue(5)：372-375,4.DOI:10.3969/j.issn.1006-2157.2016.05.005
麻芥平喘巴布剂皮肤用药安全性实验研究∗
Experimental study on dermal safety of Majie Pingchuan cataplasm
摘要
Abstract
Objective To investigate the safety of Majie Pingchuan cataplasm on skin. Methods ①A-cute toxicity test. Twelve rabbits were randomly divided into three groups with hair removed and skin damaged, systemic poisoning situation was observed after patching blank matrix cataplasm and Majie Pingchuan cataplasm. ②Skin irritation test. Sixteen rabbits were randomly divided into four groups with hair removed and skin damaged, one twelfth of one sheet of blank matrix cataplasm and Majie Pingchuan cataplasm were separately patched on left or right side skin, erythema and edema were observed in single and repeated stimulation tests. ③Skin allegy test. Thirty guinea pigs were randomly divided into three groups, one twelfth of one sheet of blank matrix cataplasm, Majie Pingchuan cataplasm, 0. 2 mL of 2,4-dinitrochlorobenzene were patched on the left side skin. On 28th day allergic reaction was observed after patching the same excitants six hours continuously on the right skin. Results In the acute toxicity test, there was no death and abnormal physiological conditions in rabbits. In the single stimulus test, erythema and edema did not appear. In the repeated stimulation tset, there was slight erythema disappearing in 48 h, and no edema. In allergy test, Majie Pingchuan cataplasm group did not appear erythema and edema, <br> the sensitization rate was 0 . Conclusion Majie Pingchuan Cataplasm had no acute toxicity and irritation on intacted or injured skin of rabbits. There was no allergic reaction in guinea pig skin. Majie Pingchuan cataplasm is safe and non-toxic.关键词
麻芥平喘巴布剂/皮肤/急性毒性/刺激性/过敏性/家兔/豚鼠Key words
Majie Pingchuan Cataplasm/skin/acute toxicity/irritation/allergy分类
医药卫生引用本文复制引用
朱文翔,刘原君,程发峰,李长香,王庆国,王雪茜..麻芥平喘巴布剂皮肤用药安全性实验研究∗[J].北京中医药大学学报,2016,39(5):372-375,4.基金项目
“重大新药创制”科技重大专项课题(No.2012ZX09103201-007) （No.2012ZX09103201-007）
