分析化学2016，Vol.44Issue(6)：979-983,5.DOI:10.11895/j.issn.0253-3820.150927
仿生提取-电感耦合等离子体-质谱法测定柏子养心片中可溶性重金属
Determination of Soluble Heavy Metals in Baizi Yangxin Tablets by Inductively Coupled Plasma Mass Spectrometry with Bionic Extraction and Microwave Digestion Technology
摘要
Abstract
Baizi Yangxin tablets are common Chinese medicine used for the treatment of heart palpitations, insomnia and irritable forgetful. To evaluate the total amount of heavy metals evaluation, artificial gastric juice was used as juice samples and the extracted soluble heavy metals were extracted by microwave digestion technology. An analytical method of bionic extraction microwave digestion with inductively coupled plasma mass spectrometry ( ICP-MS ) was established for the determination of trace metals, such as Co, Cr, Cu, Ba, Cd, Mn, Ni, Pb, Hg, Sr and Zn, in 18 batches of Baizi Yangxin tablets. The correlation coefficient of linear regression equation for different elements ranged from 0. 9989 to 1. 0000, the detection limit was 0. 19-5. 6 μg / L, and the repeatability of the method was less than 6. 2% , the precision of the RSD value was less than 5. 6% , and the recovery rate was 87. 7% -101. 9% . According to “the standard of the heavy metal in the standard of import and export of medicinal plants and preparations”, the contents of Cd, Cu and Pb in the 18 batches were not exceed the standard, but the Hg content (7. 68 mg / kg) exceeded the standard value. The bionic extraction-ICP-MS method provide a reference basis for the safety of the proprietary Chinese medicine's study.关键词
柏子养心片/朱砂/仿生提取/电感耦合等离子体质谱法Key words
Baizi Yangxin tablets/Cinnabar/Bionic extraction/Inductively coupled plasma mass spectrometry引用本文复制引用
蒋秋桃,曾丽,马杰,彭玲娜,李文莉,丁野,李洁..仿生提取-电感耦合等离子体-质谱法测定柏子养心片中可溶性重金属[J].分析化学,2016,44(6):979-983,5.基金项目
本文系国家科技部十二五专项＂重大新药创制＂项目(No.2014ZX09304-307)和国家食品药品监督管理总局2014年国家药品抽验计划资助This work was supported by the National Ministry of Science and Technology (No.2014 zx09304-307) and 2014 National Drug Sample Plan of CFDA （No.2014ZX09304-307）
