临床与病理杂志2016，Vol.36Issue(5)：568-573,6.DOI:10.3978/j.issn.2095-6959.2016.05.008
D-Dimer与胰腺癌Ⅳ期患者生存期及预后的相关性研究
Correlation analysis of plasma D-Dimer level with survival and prognosis in stageⅣ pancreatic cancer patients
摘要
Abstract
Objective: To examine the association of plasma D-Dimer levels and the prognosis of stageⅣ pancreatic cancer patients.Methods:Retrospectively analysed 90 stageⅣ pancreatic cancer patients hospitalized in Beijing Friendship Hospital Affliated Capital Medical University from January 2001 to December 2015, the correlation between plasma D-Dimer levels, the content of Fbg with clinical features and overall survival were analysed. Results: In stageⅣ pancreatic cancer patients’ D-Dimer levels increased, Fbg levels decreased, relatively the survival period was short and patients had poor physical status; D-Dimer in patients with ECOG ≥3 [(5.40±3.19) mg/L] was significantly higher than those with ECOG ≤2 [(2.42±2.33) mg/L] (P<0.01). The OS of patients with normal D-Dimer level was 9.82 months (95% CI, 8.42~11.26 months), with abnormal was 3.76 months (95% CI, 3.11~4.40 months) (P<0.05). Multivariate analysis revealed that D-Dimer was a signiifcant independent factor for OS in stageⅣ pancreatic cancer.Conclusion:D-Dimer could be the laboratory indexes of judging the prognosis of patients with stageⅣ pancreatic cancer, which abnormally elevated prompted patients with poor prognosis.关键词
D-二聚体/胰腺癌/预后Key words
D-Dimer/pancreatic cancer/prognosis引用本文复制引用
王婧,赵磊,车娟娟,李卉惠,吴军,庞歆桥,马妮娜..D-Dimer与胰腺癌Ⅳ期患者生存期及预后的相关性研究[J].临床与病理杂志,2016,36(5):568-573,6.基金项目
北京市医院管理局“青苗”计划专项经费资助(QML20150107)；北京市中医药科技发展资金项目资助(QN2015-08)；首都卫生发展科研专项基金资助(2016-4-1112)；首都医科大学基础-临床合作课题资助项目(14JL31)；首都医科大学附属北京友谊医院院启动基金资助(yyqdkt2014-10)。hTis work was supported by the Administration of Hospitals’ Youth Programme (QML20150107)(to WANG Jing), the traditional Chinese medicine science and technology development fund project of Beijing (QN2015-10)(to WANG Jing), the capital health research and development of special (2016-4-1112)(to WANG Jing), the Capital University of Medical Sciences Foundation - Clinical Cooperation Projects Funded Projects (14JL31)(to MA Nina), and the Research Foundation of Beijing Friendship Hospital (yyqdkt2014-10)(to WANG Jing), P. R. China （QML20150107）
