临床与病理杂志2016，Vol.36Issue(5)：717-728,12.DOI:10.3978/j.issn.2095-6959.2016.05.035
中枢神经系统黑色素细胞瘤临床病理分析
Melanocytoma of central nervous system：a clinicopathological analysis
摘要
Abstract
Objective:To investigate the clinicopathological features of melanocytoma of central nervous system. Methods:hTe clinical manifestations, histopathological and immunohistochemical results were analyzed in one case of melanocytoma occurring in the spinal cord with reviewing the related literatures.Results: hTe patient was a 52-year-old woman presenting a not lfexible right limb for 9 months. MRI showed that an abnormal round well-circumscribed mass was observed on vertebral 3-4 level, measured 3.7 cm × 0.8 cm × 1.3 cm. Microscopically, the tumor consisted of round, oval or spindle cells, formed tight nests with a superifcial resemblance, arranged in bunchiness or whorls. Heavily pigmented tumor cells and tumoral macrophages were seen at the periphery of nests. Melanocytoma cells showed oval or spindled nuclei with small nucleoli and clear to eosinophilic cytoplasm with variable ifne pigment. Cytologic atypia and mitoses were absent. Immunohistochemical study showed that Vimentin, HMB45, S-100, Melan-A were positive, Ki67 proliferation index was 5%~10% , other antibodies including Ckpan, EMA, GFAP, CD34, SMA, Desmin and P53 were all negative.Conclusion: Melanocytoma is a rare tumor of intermediate malignant potential, which is diffcult to be distinguished from diffuse melanocytosis and melanomatosis, malignant melanoma, and other tumors with melanin differentiation. Definitive diagnosis requires histological examination, supplemented with immunohistochemistry, radiological characterization and ultrastructural findings. The complete resection of the lump with post-operative follow-up, as well as local radiotherapy, is the main modality of treatment.关键词
黑色素细胞瘤/中枢神经系统/病理/临床Key words
melanocytoma/central nervous system/pathology/clinic引用本文复制引用
舒维清,武景波,李小静..中枢神经系统黑色素细胞瘤临床病理分析[J].临床与病理杂志,2016,36(5):717-728,12.基金项目
上海市卫生局青年科研项目(20134y008)；上海市第五人民医院院级人才培养项目(2013YYJRC05)。hTis work was supported by Youth Scientiifc Research Project of Shanghai Municipal Commission of Health and Family Planning (20134y008) and Talent Cultivation Plan of Fitfh People’s Hospital of Shanghai (2013YYJRC05), P. R. China （20134y008）
