海南医学院学报2016，Vol.22Issue(14)：1489-1492,4.DOI:10.13210/j.cnki.jhmu.20160415.008
阿托伐他汀与曲美他嗪联合治疗对冠心病患者心功能、炎症因子和内皮功能的影响
Effects of atorvastatin combined with trimetazidine on cardiac function,inflammatory factors and endothel ial function in patients with coronary artery disease
摘要
Abstract
Objective:To investigate the effects of atorvastatin combined with trimetazidine on cardiac function,inflam-matory factors and endothelial function in patients with coronary artery disease.Methods:A total of 1 64 patients with coronary artery disease were collected and randomly divided into observation group (n =83)and control group (n =81).Control group were given trimetazidine with conventional symptomatic treatments,and observation group were given atorvastatin on the basis of control group.The cardiac function,inflammatory factors and endothelial function were compared between two groups.Re-sults:No significantly differences were found in all indexes before treatment between two groups (P >0.05 ).After different treatments,left ventricular ejection fraction (LVEF)in both group increased significantly (P <0.05).The left ventricular dias-tolic dimension (LVDD),total cholesterol (TC)and low densith lipoprotein cholesterol (LDL-C)decreased significantly (P <0.05).LVEF in observation group was significantly higher,while TC and LDL-C were significantly lower than that in control group.High sensitive C reactive protein (hsCRP),tumornecrosis factor-α(TNF-α),matrix metalloproteinase-9 (MMP-9)and malondialdehyde (MDA)decreased significantly after the treatment (P <0.05).All inflammatory factors in observation group were lower than that in control group (P <0.05).Endothelin-1 (ET-1)decreased significantly after treatment,but nitrie oxide (NO)and circulating endothelial microparticles (cEMPs)increased significantly (P <0.05 ).ET-1 in observation group was lower,while NO and cEMPs were significantly higher than that in control group (P <0.05 ).Conclusion:Atorvastatin com-bined with trimetazidine can effectively improve the cardiac function,reduce the level of inflammatory factors and improve the endothelial function in patients with coronary artery disease.关键词
阿托伐他汀/曲美他嗪/心功能/炎症因子/内皮功能/冠心病Key words
Atorvastatin/trimetazidine/Cardiac function/Inflammatory factors/Endothelial function/Coronary ar-tery disease分类
医药卫生引用本文复制引用
田磊..阿托伐他汀与曲美他嗪联合治疗对冠心病患者心功能、炎症因子和内皮功能的影响[J].海南医学院学报,2016,22(14):1489-1492,4.基金项目
陕西省科技厅资助项目(2013kd4029)[Foundation Project]:This study was supported by the science foundation project of Shaanxi province (grant No ．2013 kd4029) （2013kd4029）
