海南医学院学报2016，Vol.22Issue(14)：1502-1505,4.DOI:10.13210/j.cnki.jhmu.20160513.025
瑞替普酶和重组链激酶溶栓治疗下肢深静脉血栓的凝血功能及超声特征评估
Assessment of coagulation function and ultrasound features after reteplase and recombinant streptokinase thrombolysis of lower extremity deep venous thrombosis
摘要
Abstract
Objective:To assess coagulation function and ultrasound features after reteplase and recombinant streptoki-nase thrombolysis of lower extremity deep venous thrombosis.Methods:A total of 78 patients with lower extremity deep ve-nous thrombosis who were treated in our hospital were selected as research subjects and divided into observation group (39 ca-ses)and control group (39 cases)according to different treatment regimens.Control group received recombinant streptokinase thrombolysis,observation group received reteplase thrombolysis,and then the effect of the two thrombolytic ways was evalua-ted by color Doppler ultrasonography and circulating blood test.Results:Ultrasound showed that complete recanalization rate of thrombus of observation group after treatment was higher than that of control group (P <0.05);plasma PT,APTT and TT values of observation group after thrombolysis were higher than those of control group,FIB,D-D,NO,ET,E-selectin,P-se-lectin,Hcy,CRP,IL-6,IL-8 and TNF-αvalues were lower than those of control group,and WBC,Nc and Mc cell number were less than those of control group (P < 0.05 ).Conclusion:Reteplase for thrombolysis of lower extremity deep venous thrombosis has more distinguished effects on dissolving thrombus as well as optimizing body's coagulation,inflammatory sys-tem state and other aspects,and is a more ideal thrombolytic drug.关键词
下肢深静脉血栓/瑞替普酶/重组链激酶/超声特征Key words
Lower extremity deep venous thrombosis/Reteplase/Recombinant streptokinase/Ultrasound features分类
医药卫生引用本文复制引用
熊伟..瑞替普酶和重组链激酶溶栓治疗下肢深静脉血栓的凝血功能及超声特征评估[J].海南医学院学报,2016,22(14):1502-1505,4.基金项目
武汉市卫生局临床医学科研项目(WZ09D15)[Foundation Project]:This study was supported by research projects of clinical medicine of Wuhan municipal health bureau (grant No ．WZ09D15) （WZ09D15）
