海南医学院学报2016，Vol.22Issue(14)：1515-1517,1520,4.DOI:10.13210/j.cnki.jhmu.20160601.011
拉米夫定和α-干扰素序贯治疗对慢性乙肝患者细胞免疫功能以及血清中 PD-1和 Tin-3含量的影响
Effect of the sequential therapy of lamivudine and α-interferon on cellular immune function as well as serum PD-1 and Tin-3 levels in patients with chronic hepatitis B
摘要
Abstract
Objective:To analyze the effect of the sequential therapy of lamivudine and α-interferon on cellular immune function as well as serum PD-1 and Tin-3 levels in patients with chronic hepatitis B.Methods:A total of 92 patients with chron-ic hepatitis B who were treated in our hospital from were selected as the research subjects and divided into observation group and control group (n =46)according to the random number table.Control group received lamivudine treatment alone,observa-tion group received the sequential therapy of lamivudine and α-interferon,and then differences in ultrasound-related indexes, cellular immune function as well as PD-1 and Tin-3 levels were compared between two groups.Results:After observation group received the sequential therapy of lamivudine and α-interferon,ultrasonic major diameter of left hepatic lobe and PVM values were greater than those of control group,and internal diameter of portal vein was lower than that of control group (P <0.05);CD4 + T and CD4 + T/CD8 + T values of observation group were higher than those of control group,and CD8 + T value was low-er than that of control group (P <0.05);circulating blood CD8 + T cell PD-1 and Tim-3 expression levels of observation group were lower than those of control group (P <0.05).Conclusion:Sequential therapy of lamivudine and α-interferon can optimize the cellular immune function of patients with chronic hepatitis B and inhibit the negative regulation process of immune function, and it can help to inhibit hepatitis B virus activity and disease control.关键词
慢性乙肝/拉米夫定/α-干扰素/细胞免疫Key words
Chronic hepatitis B/Lamivudine/α-interferon/Cellular immune分类
医药卫生引用本文复制引用
金燕,邱婷,吕颐菲,阎春英,王雪,段天娇,张蓉,刘贵生..拉米夫定和α-干扰素序贯治疗对慢性乙肝患者细胞免疫功能以及血清中 PD-1和 Tin-3含量的影响[J].海南医学院学报,2016,22(14):1515-1517,1520,4.基金项目
陕西省科学技术厅项目(9612012B0038)[Foundation Project]:This study was supported by science and technology department of Shaanxi province (grant No ．9612012 b0038) （9612012B0038）
