海南医学院学报2016，Vol.22Issue(14)：1557-1559,1563,4.DOI:10.13210/j.cnki.jhmu.20160513.023
妊娠糖尿病患者胰岛β细胞功能、氧化应激及脂肪因子的变化及意义
Changes and significances of islet β-cell function,oxidative stress and adipocyte factor in gestational diabetes mell itus
摘要
Abstract
Objective:To investigate the changes and significances of isletβ-cell function,oxidative stress and adipocyte factor in gestational diabetes mellitusthe.Methods:A total of 60 cases of gestational diabetes mellitus (GDM)were regarded as GDM group,a total of 60 cases of normal pregnant women were regarded as pregnant group,and a total of 60 cases of healthy women were regarded as control group.Isletβ-cell function,oxidative stress and adipocyte factor were measured and compared among the three groups.Results:For isletβ-cell function,the levels of FBG,FINS and HOMA-IR in GDM group significantly increased and the levels of HOMA-βand ISI in GDM group significantly decreased compared with control group and pregnant group,(P <0.05).For oxidative stress,the level of MDA in GDM group significantly increased but the levels of SOD,GSH and TAOC in GDM group significantly decreased compared with control group and pregnant group (P <0.05).For adipocyte factor,the levels of adiponectin and visfatin in GDM group significantly decreased and the levels of leptin and resistin in GDM group significantly increased compared with control group and pregnant group (P < 0.05 ).Conclusion:Gestational diabetes mellitus could result in impairment of islet β-cell function,decrease of insulin,oxidative stress and abnormality of adipocyte factor .关键词
妊娠糖尿病/胰岛β细胞功能/氧化应激/脂肪因子Key words
Gestational diabetes mellitus/Isletβ-cell function/Oxidative stress/Adipocyte factor分类
医药卫生引用本文复制引用
孙光宇..妊娠糖尿病患者胰岛β细胞功能、氧化应激及脂肪因子的变化及意义[J].海南医学院学报,2016,22(14):1557-1559,1563,4.基金项目
江苏省卫生厅面上科研课题(H201129)[Foundation Project]:This study was supported by scientific research project of Jiangsu province (grant No ．H201129) （H201129）
