海南医学院学报2016，Vol.22Issue(14)：1594-1596,1600,4.DOI:10.13210/j.cnki.jhmu.20160408.003
紫杉醇同步放化疗在中晚期乳腺癌细胞增殖抑制中的作用及并发症预防对策
Effect of pacl itaxel in combined with chemoradiotherapy in inhibiting the cell prol iferation in the middle and later stage of breast cancer and measures to prevent compl ications
摘要
Abstract
Objective:To study the effect of paclitaxel in combined with chemoradiotherapy in inhibiting the cell prolif-eration of breast cancer in the middle and later stage and the complication prevention measures.Methods:A total of 74 patients with middle-advanced stage breast cancer who were admitted in our hospital were included in the study and divided into the ex-periment group and the control group according to the extraction method with 37 cases in each group.The patients in the con-trol group were given the conventional radiotherapy,while the patients in the experiment group were given paclitaxel in com-bined with chemoradiotherapy.The expression levels of BaxmRNA and p53 of MCF-7 cell before and after treatment in the two groups were compared.The improvement of living qualities,the clinical efficacy,and the adverse reactions in the two groups were analyzed.Results:After treatment,the overall response rate in the experiment group [72.97% (27/37)]was significantly higher than that in the control group [40.54% (1 5/37)](P <0.05).After treatment,the expression levels of BaxmRNA and p53 of MCF-7 cell in the experiment group were significantly higher than those in the control group (P <0.05).The increasing rate of living qualities in the experiment group [62.1 6% (23/37 )]was significantly higher than that in the control group [18.92% (7/37)](P <0.05).The occurrence rates of adverse reactions in the experiment group and the control group were [13.5 1% (5/37)]and [1 6.22% (6/37)],respectively showing no significant difference (P >0.05).Conclusions:Paclitaxel in combined with chemoradiotherapy in the treatment of middle-advanced stage breast cancer can effectively inhibit the prolifera-tion of MCF-7,and enhance the living qualities,with a preferable clinical efficacy.关键词
紫杉醇/放化疗/乳腺癌/细胞增殖Key words
Paclitaxel/Chemoradiotherapy/Breast cancer/Cell proliferation分类
医药卫生引用本文复制引用
黄维,董嘉尧,周成宇,于新发..紫杉醇同步放化疗在中晚期乳腺癌细胞增殖抑制中的作用及并发症预防对策[J].海南医学院学报,2016,22(14):1594-1596,1600,4.基金项目
佛山市医学类科技攻关项目(2015AB001843)[Foundation Project]:The study was supported by the Medical Scientific and Technological Key Project of Foshan City with the number of 2015AB001843． （2015AB001843）
