口腔颌面外科杂志2016，Vol.26Issue(2)：115-118,4.DOI:10.3969/j.issn.1005-4979.2016.02.008
IgG4相关下颌下腺炎伴局部淋巴结病变的临床与病理特点分析
Clinico-pathological Characteristics of IgG4 related Sialadenitis of Submandibular Gland with Local Regional Lymphadenopathy
王木 1周炼 1赵继志 1林润台 1张韬 1余立江1
作者信息
- 1. 中国医学科学院北京协和医院口腔科，北京 100730
- 折叠
摘要
Abstract
Objective: To investigate the clinical and pathological features of IgG4 related submandibular gland sialadenitis with local regional lymphadenopathy and discuss the differential diagnosis and therapic measures. Methods:14 cases of IgG4 related submandibular gland sialadenitis, including 5 male and 9 female, age ranging from 16 to 75 were reviewed, and their clinical characteristics, radiological and pathological features were analyzed. Results: IgG4 related submandibular gland sialadenitis can occurred in different ages. Symtoms and signs consisted of enlargement of submandibular gland, xerophthalmia and lacrimal gland swelling. Laboratory finding revealed the serum IgG4 levels elevated to 3 380~21 600mg/L. Enhanced CT showed homogeneous enhancement of the gland with clear boundary. Pathology of the gland showed destruction of lobe structure, IgG4 positive plasma cell infiltration, follicular formation, storiform-type fibrosis and obliterative phlebitis appeared. Local regional lymphadenopathy presented amounts of follicular and active germinal centers. Conclusion: Immunoglobulin G4 (IgG4)-related disease is a fibro-inflammatory disease of unknown etiology,presenting a distinctive histopathological appearance. Differential diagnosis is required for local regional lymphadenopathy. General condition evaluation to excludes other organs involvement is suggested for those patients confirmed IgG4 related disease by biopsy.关键词
IgG4相关涎腺炎/下颌下腺/淋巴结病变Key words
IgG4 related sialadenitis/submandibular gland/lymphadenopathy分类
医药卫生引用本文复制引用
王木,周炼,赵继志,林润台,张韬,余立江..IgG4相关下颌下腺炎伴局部淋巴结病变的临床与病理特点分析[J].口腔颌面外科杂志,2016,26(2):115-118,4.
