中国临床保健杂志2016，Vol.19Issue(3)：225-227,3.DOI:10.3969/J.issn.1672-6790.2016.03.001
类风湿关节炎患者血清α－微管蛋白的检测及与临床实验室指标的相关性分析
The detection and correlation research of α-tubulin and disease activity parameters in rheumatoid arthritis
摘要
Abstract
Objective To detect serum α-tubulin in patients with rheumatoid arthritis (RA)and analyze the correlation between serum α-tubulin and clinical,laboratory parameters of RA,provided the theoretical basis to seek the pathogenesis of diseases.Methods Blood samples from 68 patients with RA,32 patients with Osteoarthritis(OA) and 32 healthy controls were collected.Serum α-tubulin were detected by enzyme-linked immunosorbent assay (ELISA).Difference of α-tubulin between RA patients,OA patients and healthy controls was analyzed by independent sample t test.Correlation analysis was done between α-tubulin level and clinical,laboratory parameters of RA,inclu-ding age,disease duration,number of tender joints,number of swelling joints,DAS28 score and levels of ESR,C-re-active protein (CRP),Rheumatoid Factor (RF),immunoglobin G(IgG),immunoglobin A (IgA)and immunoglobin M(IgM).Results The α-tubulin of RAwas obviously higher than that of OA patients and healthy controls (P <0. 01).Further analysis demonstrated that α-tubulin level was positively correlated with the disease duration(r =0.307, P =0.023),levels of RF and IgA(r =0.558,P =0.0001;r =0.395,P =0.004).Conclusion α-tubulin may play roles in the development o f RA and may be a potential biomarker of of RA.关键词
关节炎,类风湿/微管蛋白/自身免疫/免疫球蛋白类Key words
Arthritis,rheumatoid/Tubulin/Autoimmunity/Immunoglobulins分类
医药卫生引用本文复制引用
程永静,张春媚,陈颖娟,王芳,高明,黄慈波..类风湿关节炎患者血清α－微管蛋白的检测及与临床实验室指标的相关性分析[J].中国临床保健杂志,2016,19(3):225-227,3.基金项目
国家自然科学基金（31140008）；首都医学发展基金项目（首发-1-4051）；北京医院院内基金项目 （）
