中国临床保健杂志2016，Vol.19Issue(3)：236-239,4.DOI:10.3969/J.issn.1672-6790.2016.03.004
盐酸多奈哌齐联合尼莫地平在改善血管性痴呆患者认知功能和自理能力中的作用
Effects of donepezil hydrochloride combined with nimodipine on cognitive function and self-care ability in pa-tients with vascular dementia
摘要
Abstract
Objective To observe and analyze the effects of donepezil hydrochloride combined with nimodipin-eon cognitive function and self-care ability in patients with vascular dementia (VaD).Methods Eighty patients with VaD were selected as subjects and randomly divided into observation group and control group,40 cases in each group. The patients of control group were treated with oral donepezil hydrochloride,the patients of observation group were trea-ted with oral donepezil hydrochloride combined with nimodipine.The therapeutic effects,clinical efficiency,mini mental state examination (MMSE)score,clinical dementia scale (CDR)score,activities of daily living scale (ADL)score, Barthel index score before treatment,4 weeks and 8 weeks after treatment and incidences of adverse reactions during treatment of patients in the two groups were observed and compared.Results The distribution of the therapeutic effects and clinical efficiency of observation group were better than those of control group (U =3.512,χ2 =4.501,P <0.05). At 8th week of the treatment,the MMSE score,CDR score,ADL score,Barthel index score were improved in both groups,while these indicators in observation group was better than control group,and the differences were statistically significant (P <0.05).The difference of incidence of adverse reactions between two groups was not statistically signifi-cant (χ2 =0.251,P >0.05).Conclusion Compared with donepezil hydrochloride,donepezil hydrochloride combined with nimodipine can achieve better therapeutic effects in the treatment of VaD.Combination therapy can improve cogni-tive function and life self-care ability.关键词
痴呆,血管性/胆碱酯酶抑制剂/尼莫地平/认知功能/自理能力/治疗结果Key words
Dementia,vascular/Cholinesterase inhibitors/Nimodipine/Cognitive function/Self-care ability/Treatment outcome分类
医药卫生引用本文复制引用
张翠云,卢祖能,章军建,张贵斌,王普清..盐酸多奈哌齐联合尼莫地平在改善血管性痴呆患者认知功能和自理能力中的作用[J].中国临床保健杂志,2016,19(3):236-239,4.基金项目
湖北省科技厅2014年科技项目 （）
