河南科技大学学报（医学版）2016，Vol.34Issue(2)：87-90,4.DOI:10.15926/j.cnki.issn1672-688x.2016.02.003
切断双侧内脏大神经对犬急性坏死性胰腺炎小肠免疫功能的影响
Effect of Small Intestinal Immunological function after Cutting off the Bilateral Greater Splanchnic Nerve in the Dog with Acute Necrotizing Pancreatitis
杨天保 1孙君军 2易芳 1杨延辉1
作者信息
- 1. 河南科技大学第一附属医院，河南洛阳 471003
- 2. 河南科技大学临床医学院，河南洛阳 471003
- 折叠
摘要
Abstract
Objective To research the effect of small intestinal immune after bilateral greater splanchnic nerve transection in dog with acute necrotizing pancreatitis. Methods 17 mongrel heath dogs were randomly divided into three groups,sham operation group (SO group )5,acute necrotizing pancreatitis model group (ANP group)6,and ANP with bilateral greater splanchnic nerve transection group (GSNT group)6.The plasma levels of pancreatic amylase were monitored at 2 hours before operation.2 hours,12 hours,24 hours,3 days,5 days and 7 days after operation.At post-operation 7 days all animals were killed, small intestinal mucous was collected to detect the level of SIgA,and a section small intestinal was collected to make pathological examination and score.If the animals were dead in process of experiment,all the related data would be abandoned,but the cause of death was investigated. Results There were no significant difference between ANP group and GSNT group on the levels of plasma pancreatic amylase (P >0.05 ).The concentration of SIgA from small intestinal mucous was obvious reducing in ANP group and GSNT group compared with SO group (P <0.01 ),besides it was higher in GSNT group than ANP group(P<0.01 ).The pathological scores of small intestinal among the three groups,the ANP group and GSNT group scores were higher than that of SO group (P <0.01 ),while GSNT group was lower than ANP group(P<0.05).The ANP group had a dead animal in the experiment. Conclusion Cutting off bilateral greater splanchnic never could improve small intestinal immunological function and alleviate the degree of small intestinal damage.关键词
急性坏死性胰腺炎/内脏大神经/小肠免疫功能Key words
acute necrotizing pancreatitis/spalnchnic nerve/small intestinal immune分类
医药卫生引用本文复制引用
杨天保,孙君军,易芳,杨延辉..切断双侧内脏大神经对犬急性坏死性胰腺炎小肠免疫功能的影响[J].河南科技大学学报（医学版）,2016,34(2):87-90,4.
