日用化学工业2016，Vol.46Issue(5)：243-246,4.DOI:10.13218/j.cnki.csdc.2016.05.001
一种基于胆固醇衍生物的两亲分子的合成及其聚集行为
Synthesis of cholesterol derivative based amphiphilic molecules and their aggregation behavior
摘要
Abstract
A new kind of surfactant composed of amphiphilic molecules,potassium salt of N-cholesterol formyl glycylglycine (Chol -GG -K)employing cholesterol as the hydrophobic moiety and glycylglycine as the hydrophilic group,was synthesized and characterized. The aggregation behavior of the product in water was investigated by transmission electron microscopy (TEM )and confocal laser scanning microscopy (CLSM ). Results indicated that poly dispersive vesicles formed in Chol-GG-K aqueous solution. Besides the van der Waals interaction of cholesterol that forms strong hydrophobic effect and aggregation capacity,the hydrogen bonding of the hydrophilic group is also a driving force for the aggregation.关键词
两亲分子/胆固醇/聚集行为/囊泡/范德华力Key words
amphiphilic molecules/cholesterol/aggregation behavior/vesicle/van der Waals interaction分类
化学化工引用本文复制引用
郝姗姗,赵莉,徐宝财..一种基于胆固醇衍生物的两亲分子的合成及其聚集行为[J].日用化学工业,2016,46(5):243-246,4.基金项目
国家自然科学基金资助项目（21403010）；北京市教委科技计划面上项目（KM201510011007）；北京市教委科技计划重点资助项目 （）
