中国伤残医学2016，Vol.24Issue(10)：27-28,29,3.DOI:10.13214/j.cnki.cjotadm.2016.10.014
AKA、anti－CCP抗体检测在类风湿性关节炎诊断中的应用价值比较
Comparison of Anti-Cyclic Citrullinated Peptide Antibody、Anti-Keratin Antibody in Diagnosis of Rheumatoid Arthritis
陈红1
作者信息
- 1. 南阳医学高等专科学校，河南南阳 473058
- 折叠
摘要
Abstract
Objective:To assess the application of anti-cyclic citrullinated peptide(anti-CCP),antibody anti-keratin antibody ( AKA) in diagnosis of rheumatoid arthritis( RA) .Methods:173 patients all from the outpatient and inpatient visits to Nanyang medical college first affiliated hospital between 2014.01 to 2015.12,according to the diagnostic criteria of RA 1987 amendment by ACR,divided into 90 RA patients,83 non-RA patients.37 normal healthy people were from the examination people in the same period.Serum level of RF、AKA and anti-CCP were respectively examined by rate nephelometry method , indirect immunofluorescence( IIF) and ELISA.Ob-serve the value of three indicators in diagnosis of RA.Results: The data showed that there was a significant difference between the two methods of anti-CCP and AKA assaying(P<0.01).However,no difference was found between anti -CCP and RF assaying(P=0. 139).There was no difference between the sensitivity of anti-CCP and RF(P=0.12),the specificity of anti-CCP was higher than that of AKA (P <0.05), and RF (P <0.05).Conclusion:Compared with RF, anti-CCP and AKA have high sensitivity and specificity in diagnosis of rheumatoid arthritis, especially anti-CCP.Detect three antibodies simultaneously could improve the diagnosis rate of RA.关键词
类风湿性关节炎/抗角蛋白抗体/抗环瓜氨酸肽抗体/类风湿因子Key words
Rheumatoid arthritis/Anti-cyclic citrullinated peptide antibody/Anti-keratin antibody/Rheumatoid factor分类
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陈红..AKA、anti－CCP抗体检测在类风湿性关节炎诊断中的应用价值比较[J].中国伤残医学,2016,24(10):27-28,29,3.
