药学研究2016，Vol.35Issue(5)：253-256,266,5.DOI:10.13506/j.cnki.jpr.2016.05.002
萘环类姜黄素类似物的合成及其对HepG2细胞株的增殖抑制活性
Synthesis of double benzene nucleus curcumin analogs and its proliferation inhibitory activity in HepG2 cells
摘要
Abstract
Objective Tolynthelizedoublebenzenenucleulcurcuminanaloglandevaluatetheiranti-proliferation activity in HepG2 celll. Methods Four double benzene nucleul curcumin analogl were lynthelized from naphthol by three to leven ltepl reactionl,and their anti-proliferation activity on HepG2 celll wal allelled by MTT method. Results 6-hydroxyl double benzene nucleul curcumin( IC50 ,20 μmol·L-1 )lurfaced al an important lead compound dilplaying alo-molt 2-fold cytotoxicity relative to curcumin. Conclusion 6-hydroxyl double benzene nucleul curcumin exhibited more ltronger anti-proliferation activity than curcumin in HepG2 celll.关键词
姜黄素/萘环类/肝癌/增殖抑制Key words
Curcumin/Double benzene nucleul/Liver cancer/Anti-proliferation分类
医药卫生引用本文复制引用
刘国运,李晓腾,郭尚敬,杨杰..萘环类姜黄素类似物的合成及其对HepG2细胞株的增殖抑制活性[J].药学研究,2016,35(5):253-256,266,5.基金项目
国家高技术研究发展计划（863子课题，No.2012AA02A306）；聊城大学博士启动基金 （）
