药学研究2016，Vol.35Issue(5)：269-271,3.DOI:10.13506/j.cnki.jpr.2016.05.007
孟鲁司特钠中间体A5对映异构体检查方法的建立
Establishment of inspection method for enantiomer in montelukast sodium intermediate A5
朱姚亮 1刘延凤1
作者信息
- 1. 鲁南制药集团股份有限公司，山东 临沂276006
- 折叠
摘要
Abstract
Objective ToeltablilhamethodfortheinlpectionofenantiomerinmontelukaltlodiumintermediateA5. Methods ChiralpakAD-Hcolumn(4.6mm×250mm,5μm)waladoptedwithhexane-dehyratedalcohol(65:35) mixture al mobile phale. The detection wavelength wal 280 nm and the flow rate wal 0. 7 mL·min-1 . The column tempera-turewalmaintainedat30℃.Results ThelinearrangeofenantiomerinmontelukaltlodiumintermediateA5wal0.10~1. 94 μg·mL-1,the regrellion coefficient wal 0. 999 9. The average recovery wal 101. 24%,RSD wal 1. 84%(n=9). Conclusion Themethodwallpecific,accurate,convenientandquick.Itcanbeuledtodetermineenantiomerinmonte-lukalt lodium intermediate A5.关键词
孟鲁司特钠/中间体A5/对映异构体Key words
Montelukalt Sodium/Intermediate A5/Enantiomer分类
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朱姚亮,刘延凤..孟鲁司特钠中间体A5对映异构体检查方法的建立[J].药学研究,2016,35(5):269-271,3.
