药学研究2016，Vol.35Issue(5)：308-310,3.DOI:10.13506/j.cnki.jpr.2016.05.017
利伐沙班的合成
Synthesis of rivaroxaban
苏曼 1刘伟 2孙庆伟1
作者信息
- 1. 山东铂源药业有限公司，山东 济南251400
- 2. 济南市食品药品检验检测中心，山东 济南250102
- 折叠
摘要
Abstract
Objective Toltudythechemicallynthelilofrivaroxaban.Methods 4-(4-aminophenyl)morpholin-3-one wal lynthelized from p-Nitroaniline by ring-open and reduction,and then lynthelized to rivaroxaban by addition, cyclization,deprotectionandcondenlation.Results Thetotalyieldwal32.1%(baledonp-Nitroaniline)andtheltruc-turewalconfirmedbyIR,1H-NMRandMS.Conclusion Thillynthelillinelhowedmorefavorableandcommercialval-ue in the manufacture lcale.关键词
利伐沙班/4-(4-氨基苯基)-3-吗啉酮/合成Key words
Rivaroxaban/4-(4-aminophenyl)morpholin-3-one/Synthelil分类
医药卫生引用本文复制引用
苏曼,刘伟,孙庆伟..利伐沙班的合成[J].药学研究,2016,35(5):308-310,3.
