山东医药2016，Vol.56Issue(14)：14-17,4.DOI:10.3969/j.issn.1002-266X.2016.14.005
北京市不同性别成年人群代谢综合征发生与淋巴细胞数量的关联性
Association between metabolic syndrome and the count of lymphocyte in male and female Beijing adults’population
摘要
Abstract
Objective To explore the association between the count of lymphocyte and the occurrence of metabolic syndrome (Mets)in a cohort study in male and female Beijing adults specifically in gender.Methods Clinical data of 7 489 cases who took at least 3 health examination from 1st January 2007 to 31th December 2012 were retrospectively ana-lyzed in Beijing Electric Power Hospital and Beijing Xiaotangshan Hospital.The count of lymphocyte of research objects was obtained from the blood routine examination.And the lymphocytes were divided into 4 levels according to the quartile (Q1≤25%,Q2:25%-50%,Q3:50%-75%,Q4>75%)in gender.Metabolic syndrome was diagnosed by the last data of health examination.Generalized estimating equation model was used to assess the relationship between metabolic syndrome and the lymphocyte.Results During the 5 years’follow-up,378 cases appeared MetS,including 203 males and 175 fe-males.And the incidence density of Mets was 12.67 per 1000 person-years.Compared with Q1,the males’BMI increased in Q4 (RR=2.200 8,95% CI:1.090 8-2.045 7 ),and the males’TG increased in Q1,Q2 and Q3(RR=1.208 4, 1.442 5,1.707 7,95%CI:1.032 3-1.414 6,1.210 3-1.7192,1.406 5-2.073 5).Compared with Q1,the females whose lymphocytes were Q4 increased the risk of MetS (RR=2.200 8,95%CI:1.221 9-3.964 0).Conclusions The increase of males’lymphocytes may associate with the increase of BMI and TG,and the increase of females’lymphocytes may associ-ate with the occurrence of MetS in Beijing adults.关键词
代谢综合征/淋巴细胞数量/性别/队列研究/广义估计方程/北京市Key words
metabolic syndrome/lymphocyte/gender/cohort studies/generalized estimating equations/Beijing分类
医药卫生引用本文复制引用
董静,杨昆,陶丽新,周锋,师宁,闫焱,郭秀花..北京市不同性别成年人群代谢综合征发生与淋巴细胞数量的关联性[J].山东医药,2016,56(14):14-17,4.基金项目
国家自然科学基金资助项目（81373099；81001281；81502886）；北京市自然科学基金资助项目（7131002）；北京市优秀人才青年骨干个人项目（2014000020124G150）。 （）
