上海针灸杂志2016，Vol.35Issue(5)：579-582,4.DOI:10.13460/j.issn.1005-0957.2016.05.0579
早期针刺夹脊穴对 MCAO 大鼠脑纹状体β-内啡肽和强啡肽水平的影响
Effect of Early Acupuncture at Huatuo Jiajipoints on Striatalβ-endorphin and Dynorphin Levels in MCAO Rats
摘要
Abstract
Objective To investigate the effect of early acupuncture at Huatuo jiaji points on striatalβ-endorphin and dynorphin levels in rats with post-stroke limb spasm.Methods Seventy SD rats were randomized into group A (normal) of 9 rats and group B (sham operation) of 10 rats. After a model of post-stroke limb spasm was made in the remaining rats, they were randomized into groups C (model), D (acupuncture at Huatuo jiaji points) and E (baclofen). Group D received acupuncture at Huatuo jiaji points and group E, an oral gavage of baclofen tablets. After seven days of treatment, striatalβ-endorphin and dynorphin levels were neasured by radioimmunoassay.Resultsβ-endorphin levels increased significantly in groups C, D and E compared with groups A and B (P<0.01) and also in groups D and E compared with group C (P<0.01,P<0.05). There was no statistically significant difference inβ-endorphin levels between groups D AND E (P>0.05). Dynorphin levels increased significantly in groups C, D and E compared with groups A and B (P<0.05,P<0.01). There was no statistically significant difference in dynorphin levels between groups D and E (P>0.05).Conclusions Acupuncture at Huatuo jiaji points can increase striatalβ-endorphin levels but not change striatal dynorphin levels, which conforms to the relationship between enkephalin and spasm, and improve the animal’s spasticity.关键词
针刺疗法/穴,夹脊/痉挛/β-内啡肽/强啡肽/中风Key words
Acupuncture therapy/Points, Huatuo jiaji/Spasm/β-Endorphin/Dynorphin/Stroke分类
医药卫生引用本文复制引用
王春琛,王麟鹏..早期针刺夹脊穴对 MCAO 大鼠脑纹状体β-内啡肽和强啡肽水平的影响[J].上海针灸杂志,2016,35(5):579-582,4.基金项目
国家自然科学基金项目(81072859) （81072859）
北京市科技计划研发攻关类重大课题(D09050703550902) （D09050703550902）
北京市自然科学基金项目(7102084) （7102084）
