牙周炎对小鼠脾脏巨噬细胞表型的影响OA北大核心CSTPCD
Effects of periodontitis on the phenotype and secretion function of macrophages in C57 BL/6J mice model
目的:研究实验性牙周炎模型小鼠的脾脏巨噬细胞表型、分泌功能及相对数量变化,以探究牙周炎对脾脏巨噬细胞的影响。方法:22只22周龄小鼠随机分为真性结扎组( P10d 组)和假性结扎对照组( C 组),各11只牙周结扎10 d后处死。流式细胞术检测单核巨噬细胞及其M1、M2表型的比例。实时荧光定量PCR法检测脾脏中巨噬细胞相关抗炎型细胞因子IL-1β,抑炎型细胞因子IL-10促炎型 mRNA相对表达水平的差异。结果:与C组相比,牙周炎组的M1型巨噬细…查看全部>>
Objective To explore the splenic macrophages phenotype and secretory function of mice with periodontitis, so as to explore effects of periodontitis on macrophages. Methods 22 mice were randomly divided into periodental ligation group (group P10d ) and pseudo periodental ligation control group (group C), with 11 mice in each group. The experimental periodental ligation on mice lasted for 10 days before they were sacrificed. Flow cytometry was applied to detec…查看全部>>
徐怡馨;章锦才;轩东英;余挺;王向丽
510280 广州市,南方医科大学附属口腔医院,广东省口腔医院510280 广州市,南方医科大学附属口腔医院,广东省口腔医院510280 广州市,南方医科大学附属口腔医院,广东省口腔医院510280 广州市,南方医科大学附属口腔医院,广东省口腔医院510280 广州市,南方医科大学附属口腔医院,广东省口腔医院
牙周炎脾脏巨噬细胞表型
PeriodontitisSpleenMacrophage phenotye expression
《实用医学杂志》 2016 (10)
巨噬细胞介导牙周炎促进肥胖性胰岛素抵抗的表观遗传调控
1568-1570,3
国家自然科学基金资助项目(编号81371151)
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