实用医学杂志2016，Vol.32Issue(10)：1631-1634,4.DOI:10.3969/j.issn.1006-5725.2016.10.023
溃疡性结肠炎肠道菌群失调与免疫球蛋白水平的相关性
Relationship of intestinal flora imbalance and immunoglobulin in patients with ulcerative colitis
摘要
Abstract
Objective To investigate the relationship among the activity of diseases , the alteration of intestinal flora and the serum immuoglobulin (Ig) in patients with ulcerative colitis (UC) and to further evaluate the clinical value of fecal cue ratio in assessing humoral immune abnormalities. Methods Clinical data of 401 UC patients admitted in Peking University First Hospital from January 2013 to May 2015 were analyzed. According to Mayo index , patients were divided into inactive and active groups , and the active group was further divided into the mild, moderate and severe group. Serum immunoglobulin (IgG, IgM, IgA, C3 and C4) and fresh fecal bacteria cue proportion were measured. Statistical analysis was made to find the relevance among the above indexes. Results With the increase of disease activity , the intestinal flora imbalance aggravated (Spearmann correlation coefficient equals 0.295, P < 0.05) and serum IgM decreased significantly. However, serum C3 increased obviously. Serum C4 increased in mild to moderate group but decreased significantly in severe group. With the aggravation of intestinal flora imbalance , serum IgM and IgA decreased but C3 increased (P < 0.05). Conclusions The measurement of intestinal flora cue proportion, Ig, C3 and C4 may contribute to better determining the severity of diseases and provide beneficial information for therapy.关键词
溃疡性结肠炎/肠道菌群失调/免疫球蛋白/粪便球杆比Key words
Ulcerative colitis/Intestinal flora imbalance/Immunoglobulin/Fecal cue ratio引用本文复制引用
王艳,李俊霞,王化虹,刘新光..溃疡性结肠炎肠道菌群失调与免疫球蛋白水平的相关性[J].实用医学杂志,2016,32(10):1631-1634,4.
