天津中医药2016，Vol.33Issue(5)：265-269,5.DOI:10.11656/j.issn.1672-1519.2016.05.03
扶正解毒祛瘀法方药择时给药防治非小细胞肺癌化疗所致骨髓抑制的临床研究
Clinical research on the traditional Chinese medicine of Fuzheng jiedu Quyu method to choose time for the prevention and treatment of bone marrow suppression caused by chemotherapy in non-small cell lung cancer
摘要
Abstract
[Objectives] To observe clinical efficacy of the prevention and treatment bone marrow suppression caused by chemotherapy by traditional Chinese medicine of Fuzheng Jiedu Quyu method. [Methods] Using completely randomized method, 60 cases of The First Affiliated Hospital of Tianjin Universi of Traditional Chinese Medicine non-small cell lung cancer patients were randomly divided into group A (7 days in advance using traditional Chinese medicine of Fuzheng Jiedu Quyu method joint chemotherapy group) and group B (pure chemotherapy group).We observe Chinese herbal 7 days in advance to bone marrow suppression in patients with non-small cell lung cancer chemotherapy the incidence of cytokines, immune function, and the influence of the quality of life. [Results] Chemotherapy after two cycles, the incidence of bone marrow suppression and bone marrow inhibition of classification, treatment group reduce the incidence of bone marrow suppression,it has statistical significance (P<0.05);compared with control group, treatment group decline in WBC and RBC 1, 2 degrees, it has statistical significance (P<0.05). After the first cycle of chemotherapy, in the aspect of cytokines, cell factor gm-csf, between the two groups of IFN-gamma is statistically significant. In terms of quality of life,patients KPS score comparison between the two groups have statistical significance (P<0.05). [Conclusion] Compared with the pure chemotherapy, using Chinese medicinec 7 days in advance combination chemotherapy can effectively reduce non-small cell lung cancer incidence of bone marrow suppression caused by chemotherapy, regulate cytokine concentrations, and to some extent improve the patient's quality of life.关键词
扶正解毒祛瘀法/骨髓抑制/择时给药Key words
Fuzheng Jiedu Quyu method/bone marrow suppression/time-choosing administration分类
医药卫生引用本文复制引用
杨佩颖,李小江,张瑶,于晓宇,贾英杰..扶正解毒祛瘀法方药择时给药防治非小细胞肺癌化疗所致骨髓抑制的临床研究[J].天津中医药,2016,33(5):265-269,5.基金项目
国家自然科学基金资助项目(81273937) （81273937）
天津市抗癌重大专项攻关计划项目(12ZCDZSY15800) （12ZCDZSY15800）
天津市科委自然科学基金青年项目(13JCQNJC10900). （13JCQNJC10900）
