天津中医药2016，Vol.33Issue(5)：299-302,4.DOI:10.11656/j.issn.1672-1519.2016.05.11
桃核承气汤对糖尿病大鼠大血管纤维病变Toll样受体通路作用研究
Study of Taohe Chengqi Tang on Toll-like receptor passage in diabetic vascular fibrosis with rats
摘要
Abstract
[Objective] Using Western blotting to detect the expression of TLR-2, TLR-4 which from the diabetes rats in lower limb femoral vessels, and observing by Taohe Chengqi Tang (THCQT) impact on related indicators, revealing intervention mechanisms of THCQT on diabetic vascular fibrosis. [Methods] The 170 male SD rats were divided into five groups, A-the normal control group (n=30), other 140 making diabetes model and succeed 123, randomly divided into 4 groups:B-model control group (n=31), C-Chinese high-dose treatment group (n=30), D-medicine dose treatment group (n=31), E-low dose treatment group (n=31). A group was no drug intervention , group B received 0.9%saline 10 mL/(kg·d) orally, group C was given THCQT 1.8 g/kg, D group was given THCQT 0.9 g/kg, E group was given THCQT 0.45 g/kg. Drug intervention first weeks, 12 weeks , 20 weeks , the rats were sacrificed according to plan, the groups were drawn, preserved specimens, Western blotting detection TLR-2 and TLR-4 expression. [Results] TLR-2 and TLR-4 has significant expression in diabetic rat femoral artery, TCD THCQT can effectively reduce the expression of TLR-2 and TLR-4. [Conclusion] Diabetic vascular disease may be associated with Toll-like receptor pathway and apoptosis, TCD THCQT can obviously improve diabetic vascular lesions, and slow down the fibrosis process, its intervention effect associated with dosage and duration.关键词
大血管纤维化/桃核承气汤/Toll样受体2/Toll样受体-4Key words
macrovascular fibrosis/THCQT/Toll-like receptor-2/Toll-like receptor-4分类
医药卫生引用本文复制引用
徐阳,王军,武海阔..桃核承气汤对糖尿病大鼠大血管纤维病变Toll样受体通路作用研究[J].天津中医药,2016,33(5):299-302,4.基金项目
国家自然科学基金项目(81173268). （81173268）
