天津中医药2016，Vol.33Issue(5)：311-313,3.DOI:10.11656/j.issn.1672-1519.2016.05.14
不同浓度葛根素溶液对人皮肤成纤维细胞生物学效应的影响
Biological effects of different concentrations of Puerarin solution on human skin fibroblast
摘要
Abstract
[Objective] To observe biological effects of different concentrations of puerarin solution on proliferation of human skin fibroblasts (HDF). [Methods] Cultivated human skin fibroblasts in vitro, observed biological effects of puerarin solutions of 100, 200, 300, 400, 500μg/mL five different drug concentrations on HDF. [Results] Compared with control group, drug concentration of 100, 200, 300, 400μg/mL of puerarin solution had no influence on biological effects of HDF. Drug concentration of 500μg/mL of puerarin solution inhibited proliferation of HDF, had a certain damage on cell membranes of HDF. [Conclusion] Puerarin solution of 500μg/mL can inhibit proliferation of HDF and have damage on cell membranes of HDF cultured in vitro, this drug concentration can be used as the dose of HDF intervention, will play a role in treatment of scar tissue.关键词
葛根素/人皮肤成纤维细胞/药物浓度/生物学效应Key words
Puerarin/human skin fibroblasts/drug concentration/biological effect分类
医药卫生引用本文复制引用
岳冬梅,阎冰,马轶文,王益民,孟庆楠..不同浓度葛根素溶液对人皮肤成纤维细胞生物学效应的影响[J].天津中医药,2016,33(5):311-313,3.基金项目
国家自然科学基金项目(30873467). （30873467）
