外科理论与实践2016，Vol.21Issue(3)：252-256,5.DOI:10.16139/j.1007-9610.2016.03.015
代谢综合征与乳腺癌发生关系的研究
Study on relationship between metabolic syndrome and breast cancer
摘要
Abstract
Objective Metabolic syndrome (MS) may be associated with development of breast cancer. In this study, we aim to evaluate the prevalence of MS in patients with breast disease and the relationship between MS and breast cancer. Methods The patients with breast disease who had surgery in Comprehensive Breast Health Center , Department of Surgery of Ruijin Hospital from Dec 2012 to Mar 2015 were enrolled. Measurement was made and recorded including body mass index(BMI), blood pressure, blood lipids and glucose combined with clinical factors. Differences was compared between benign breast diseases and brease cancer. Results A total of 2 816 cases were enrolled including 1 500 cases with benign breast diseases and 1 316 cases with breast cancer. BMI was (22.8±3.1) in benign breast disease group and (23.4±3.2) in breast cancer group (P=0.018). MS was diagnosed in 131 (8.7%) cases in benign breast diseases group and 191(14.5%) cases in breast cancer(P<0.001). Univariate analysis showed that the difference of BMI and MS between benign breast disease group and breast cancer groups was statistically significant ( P<0.05). It was shown by multivariate analysis that obesity was independent risk factor of breast cancer alone among the factors of metabolic abnormality ( P=0 . 010 ) . Compared with cases with BMI<25.0, obesity cases had higher breast cancer incidence risk (OR=1.28, 95%CI=1.06-1.56). Conclusions MS was found in 14.5%breast cancer patients more than in the patients with benign breast disease. Obesity may increase breast cancer incidence which needs further study.关键词
代谢综合征/肥胖/乳腺癌/高危因素Key words
Metabolic syndrome/Obese/Breast cancer/High risk factor分类
医药卫生引用本文复制引用
章蔚,童一苇,陈小松,王亘,梁跃,李亚芬,陈伟国,沈坤炜..代谢综合征与乳腺癌发生关系的研究[J].外科理论与实践,2016,21(3):252-256,5.基金项目
国家自然科学基金(81472462)；上海市科学技术委员会科技创新行动计划（14411950200,14411950201) （81472462）
