中国组织工程研究2016，Vol.20Issue(19)：2864-2871,8.DOI:10.3969/j.issn.2095-4344.2016.19.019
机械因素对组织工程干细胞增殖和分化的影响
Effects of mechanical factors on proliferation and differentiation of tissue-engineered stem cells
摘要
Abstract
BACKGROUND:With the development of tissue engineering technology and the deep research of tendon regeneration, many problems caused by traditional tendon transplantation wil be solved. OBJECTIVE:To evaluate and prospect the effects of corresponding mechanical systems on seeding cel s based on the characters of tendon, stem cel s as wel as mechanical systems. METHODS:CBM, CNKI, CqVip and PubMed databases were retrieved for reviews and articles related to tissue-engineered tendon published from January in 2005 to December in 2015. The keywords were“tissue engineering, tendon, tendon stem cel , mechanical stimulation and seeding cel s”in Chinese and English, respectively. Final y a total of 63 articles were selected for overview. RESULTS AND CONCLUSION:As al kinds of stem cel s and the corresponding mechanical systems exhibit advantages and disadvantages when applied for tissue engineering, it is advisable to make appropriate choices according to the research needs. Tendon stem cel s show a broad application prospect in tendon regeneration, which wil grow into required tendon tissues through appropriate, accurate and gentle mechanical stimulations, thereby providing another alternative to improve the tendon healing.关键词
干细胞/分化/肌腱干细胞/种子细胞/体外培养/力学刺激/国家自然科学基金分类
医药卫生引用本文复制引用
姜东,王继宏..机械因素对组织工程干细胞增殖和分化的影响[J].中国组织工程研究,2016,20(19):2864-2871,8.基金项目
国家自然科学基金(81441117)，课题名称持续牵张应力刺激对兔跟腱损伤修复早期生物力学及相关因子表达的影响 （81441117）
