中国当代儿科杂志2016，Vol.18Issue(6)：488-491,4.DOI:10.7499/j.issn.1008-8830.2016.06.004
加温湿化高流量鼻导管吸氧在32周以下早产儿撤机中的疗效比较
Efficacy of heated humidified high-flow nasal cannula in preterm infants aged less than 32 weeks after ventilator weaning
摘要
Abstract
ObjectiveTo investigate the efifcacy of heated humidiifed high-lfow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP) in preterm infants aged 26-31+6 weeks with respiratory distress syndrome after ventilator weaning.MethodsA total of 161 preterm infants were randomly divided into two groups after ventilator weaning: HHHFNC treatment (n=79) and nCPAP treatment (n=82). The two groups were subdivided into 26-28+6 weeks and 29-31+6 weeks groups according to the gestational age. The treatment failure rate, reintubation rate within 7 days after extubation, incidence of complications, and mortality during hospitalization were compared between the two groups.ResultsThe treatment failure rate and reintubation rate showed no signiifcant differences between the HHHFNC and nCPAP groups. The preterm infants aged 26-28+6 weeks in the HHHFNC group had a signiifcantly higher treatment failure rate than those in the nCPAP group (P<0.05), while the reintubation rate showed no signiifcant difference. As for the preterm infants aged 29-31+6 weeks, the treatment failure rate and reintubation rate showed no significant differences between the two groups. The incidence of complications and mortality showed no significant differences between the HHHFNC and nCPAP groups.ConclusionsIn preterm infants aged 29-31+6 weeks, HHHFNC has a similar efifcacy as nCPAP after ventilator weaning, while in those aged less than 29 weeks, HHHFNC should be used with great caution if selected as the ifrst-line noninvasive respiratory support.关键词
加温湿化高流量鼻导管吸氧/鼻塞持续气道正压/撤机/早产儿Key words
Heated humidified high-flow nasal cannula/Nasal continuous positive airway pressure/Ventilator weaning/Preterm infant引用本文复制引用
康文清,许邦礼,刘大鹏,张耀东,郭静,李朝晖,周炎娟,熊虹..加温湿化高流量鼻导管吸氧在32周以下早产儿撤机中的疗效比较[J].中国当代儿科杂志,2016,18(6):488-491,4.基金项目
郑州市普通科技攻关项目（20140510）。 （）
