中国当代儿科杂志2016，Vol.18Issue(6)：541-544,4.DOI:10.7499/j.issn.1008-8830.2016.06.014
先天性肛门闭锁的影响因素分析
Risk factors for congenital anal atresia
摘要
Abstract
ObjectiveTo investigate the risk factors for the development of congenital anal atresia in neonates. MethodsA total of 70 neonates who were admitted to 17 hospitals in Foshan, China from January 2011 to December 2014 were enrolled as case group, and another 70 neonates who were hospitalized during the same period and had no anal atresia or other severe deformities were enrolled as control group. Univariate and multivariate logistic regression analyses were used to investigate the risk factors for the development of congenital anal atresia.ResultsThe univariate analysis revealed that the age of mothers, presence of oral administration of folic acid, infection during early pregnancy, and polyhydramnios, and sex of neonates showed signiifcant differences between the case and control groups (P<0.05). The multivariate logistic regression analysis revealed that infection during early pregnancy (OR=18.776) and male neonates (OR=9.304) were risk factors for congenital anal atresia, and oral administration of folic acid during early pregnancy was the protective factor (OR=0.086).ConclusionsInfection during early pregnancy is the risk factor for congenital anal atresia, and male neonates are more likely to develop congenital anal atresia than female neonates. Supplementation of folic acid during early pregnancy can reduce the risk of congenital anal atresia.关键词
先天性肛门闭锁/危险因素/新生儿Key words
Congenital anal atresia/Risk factor/Neonate引用本文复制引用
高晓燕,张爱民,廖铁军,郭伟忠,潘学军,潘敏仪,肖厚兰,朱金林,吴龙耀,黄祖琳,高平明,吴时光,麦智广,周杰,黄润忠,张水堂,钟焕琼,廖友明..先天性肛门闭锁的影响因素分析[J].中国当代儿科杂志,2016,18(6):541-544,4.基金项目
佛山市科技局重点攻关项目（2011AA100211）。 （）
